ensmusg00000068196 (Col8a1)

mus musculus

collagen, type VIII, alpha 1

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Mus musculus
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Showing 56 experiments:
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Created with Highcharts 6.2.0adrenal glandcaudal brain neural epitheliumdorsal raphe nucleushypothalamusmaxillary archovaryspleenvesicular glandaxillary lymph nodebraincolondentate gyrus of hippocampal formationeyeball of camera-type eyehead mesenchymeintestinelivermesodermolfactory brainplacentasinoatrial nodesubventricular zonetracheazone of skin
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49 FANTOM5 project - adult
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49 FANTOM5 project - neonate
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49 FANTOM5 project - juvenile
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49 FANTOM5 project - embryonic day 18
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49 FANTOM5 project - embryonic day 16
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49 FANTOM5 project - embryonic day 17
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49 FANTOM5 project - embryonic day 15
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49 FANTOM5 project - embryonic day 14
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49 FANTOM5 project - embryonic day 12
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9 in 3 strains - CD1
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9 in 3 strains - DBA/2J
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49 FANTOM5 project - embryonic day 13
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9 in 3 strains - C57BL/6
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14 - embryonic day 10.5
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Vertebrates
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Mammalian Kaessmann
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14 - embryonic day 9.5
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4 Bonthuis et al - (CastEiJ X …
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Developing gut
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49 FANTOM5 project - embryonic day 11
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Gregg et al - CAST/EiJ
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Gregg et al - C57BL/6J
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Gregg et al - (CAST/EiJ X C57BL/6J)F1
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Gregg et al - (C57BL/6J X CAST/EiJ)F1
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4 Bonthuis et al - CastEiJ
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4 Bonthuis et al - (C57BL/6J X …
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Mernberger et al 2019 - Organism Part
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4 Bonthuis et al - C57BL/6J
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Fat and muscle
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49 FANTOM5 project - embryonic day 17.5
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49 FANTOM5 project - embryonic day 14.5
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3 Soumillon et al
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14 - embryonic day 8.5
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Sun et al., 2020 - Organism part
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4 Bonthuis et al - Idaho derived wild …
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Linscheid et al. 2019 - organism part
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Deshmukh et al., 2015 - organism part
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Huttlin et al., 2010 - tissues - brain, …
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Experimental variables
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Log2-fold changeSpeciesGene nameComparisonExperimental variablesExperiment name
Adjusted p-valueLog2-fold change
1.3413 × 10-34-8.3
Col8a1'induced extraembryonic endoderm stem cell; grown in ES cell medium' vs 'mouse embryonic fibroblast; control'cell type, growth conditionOSKM induce extraembryonic endoderm stem (iXEN) cells in parallel to iPS cells
Adjusted p-valueLog2-fold change
2.4662 × 10-56.7
Col8a1'Lin- Dapi-EpCAM- CD31+td-tomato+' vs 'Lin- Dapi-EpCAM- CD31+td-tomato-' in 'vascular endothelial cell'cell type, phenotypeThymic T-cell progenitor development is supported by membrane bound Kit ligand provided by a combined vascular endothelial and epithelial niche.
Adjusted p-valueLog2-fold change
4.9131 × 10-10-5.6
Col8a1'extraembryonic endoderm stem cell; grown in XEN cell medium' vs 'mouse embryonic fibroblast; control'cell type, growth conditionOSKM induce extraembryonic endoderm stem (iXEN) cells in parallel to iPS cells
Adjusted p-valueLog2-fold change
2.7518 × 10-51-5.3
Col8a1'extraembryonic endoderm stem cell; grown in ES cell medium' vs 'mouse embryonic fibroblast; control'cell type, growth conditionOSKM induce extraembryonic endoderm stem (iXEN) cells in parallel to iPS cells
Adjusted p-valueLog2-fold change
2.3458 × 10-6-5.3
Col8a1'induced extraembryonic endoderm stem cell; grown in XEN cell medium' vs 'mouse embryonic fibroblast; control'cell type, growth conditionOSKM induce extraembryonic endoderm stem (iXEN) cells in parallel to iPS cells
Adjusted p-valueLog2-fold change
4.144 × 10-234.7
Col8a1'PTEN null, P53-/-' vs 'wild type genotype'genotypeRNA seq of prostate gland from WT, PTEN pc -/- and PTEN pc-/-;P53 -/- mice
Adjusted p-valueLog2-fold change
1.4346 × 10-224.7
Col8a1'Salmonella enterica serovar Typhimurium' vs 'control' in 'bone marrow macrophage from 129P2 mouse strain'clinical information, infectGene expression profiles of mouse embryonic stem cell derived macrophages infected with Salmonella typhimurium
Adjusted p-valueLog2-fold change
5.0471 × 10-314.6
Col8a1'carotid body' vs 'adrenal medulla'organism partExpression profile of mouse carotid body and adrenal medulla [RNA-Seq]
Adjusted p-valueLog2-fold change
3.8203 × 10-324.2
Col8a1'tamoxifen induction at 2 months, wait 1 months' vs 'no tamoxifen induction' in 'luminal cell of prostate epithelium; Nkx3.1-CreERT2 targeted allele'cell type, genotype, growth conditionTranscription profiling by high throughput sequencing of PIN/tumor lesions from basal or luminal origins at time points at which mice displayed similar histopathological phenotypes
Adjusted p-valueLog2-fold change
5.7247 × 10-294.2
Col8a1'tamoxifen induction at 2 months, wait 3 months' vs 'no tamoxifen induction' in 'luminal cell of prostate epithelium; Nkx3.1-CreERT2 targeted allele'cell type, genotype, growth conditionTranscription profiling by high throughput sequencing of PIN/tumor lesions from basal or luminal origins at time points at which mice displayed similar histopathological phenotypes
Adjusted p-valueLog2-fold change
1.8281 × 10-83.8
Col8a1'conditional Kras and p53 mutation induced soft tissue sarcoma' vs 'normal'diseaseTranscription profiling by array of mouse soft tissue sarcoma samples induced by conditional mutations of Kras and p53 against healthy muscles from mice of the same genotype but no induced sarcoma
Adjusted p-valueLog2-fold change
3.6766 × 10-83.8
Col8a1'osteosarcoma' vs 'control'disease, genotypeMouse Model of Clear Cell Sarcoma
Adjusted p-valueLog2-fold change
3.7663 × 10-7-3.7
Col8a1'pkd1 knockout' vs 'wild type' in 'presence of fluid flow'genotype, stimulusTranscription profiling by array of mouse kidney epithelial cells from pkd1 knockout and wild type in response to fluid flow
Adjusted p-valueLog2-fold change
2.0963 × 10-53.7
Col8a1'Salmonella enterica serovar Typhimurium' vs 'control' in 'derived macrophage from E14 cell line'clinical information, infectGene expression profiles of mouse embryonic stem cell derived macrophages infected with Salmonella typhimurium
Adjusted p-valueLog2-fold change
2.1985 × 10-4-3.7
Col8a1'heat-shocked at 42 degreeC' vs 'grown at 33 degreeC' in 'wild type'genotype, growth conditionTranscription profiling by array of mouse wild type and Htt mutant striatal cells upon heat shock
Adjusted p-valueLog2-fold change
2.5991 × 10-73.6
Col8a1'wild type; mature luminal' vs 'wild type; MaSC/basal'cell type, genotypeExpression data from sorted control and Pygo2-null mouse mammary stem/basal cells
Adjusted p-valueLog2-fold change
1.606 × 10-23.6
Col8a1'Lgr6-positive hair follicle/sebaceous gland cell' vs 'Lgr6-positive basal interfollicular epidermis cell'cell typeTranscription profiling of Lgr6+ keratinocyte populations in the epidermis and hair follicle
Adjusted p-valueLog2-fold change
1.2104 × 10-11-3.5
Col8a1'induced neural stem cell' vs 'mouse embryonic fibroblast cell'cell typeGene expression profile of mouse induced neural stem cells
Adjusted p-valueLog2-fold change
1.4525 × 10-73.5
Col8a1'heart-specific Mdm2 knockout; 14 day' vs 'heart-specific Mdm2 knockout; 7 day'phenotype, timeTranscription profiling of heart tissue from mice with heart-specific knockout of p53 and Mdm2
Adjusted p-valueLog2-fold change
1.0281 × 10-3-3.5
Col8a1'heat-shocked at 42 degreeC' vs 'grown at 33 degreeC' in 'HdhQ111 knock-in'genotype, growth conditionTranscription profiling by array of mouse wild type and Htt mutant striatal cells upon heat shock
Adjusted p-valueLog2-fold change
1.4408 × 10-753.4
Col8a1'human-Mfn2 T111A/S442A-overexpressing (Mfn2AA)' vs 'wild type' in '5 week; left ventricle'age, genotype, organism partTranscription profiling by high throughput sequencing of a mitofusin 2 (Mfn2) mutant in mouse
Adjusted p-valueLog2-fold change
4.2607 × 10-63.4
Col8a1'infarct and border region of left ventricle 5 days post-myocardial infarction; C57BL/6J' vs 'left ventricle at baseline (no myocardial infarction) in the same region as the infarct in post-myocardial infarction hearts; C57BL/6J'clinical information, strainExpression data from C57BL/6J and MRL/MpJ hearts following acute myocardial infarction
Adjusted p-valueLog2-fold change
5.058 × 10-6-3.4
Col8a1'pkd1 knockout' vs 'wild type' in 'absence of fluid flow'genotype, stimulusTranscription profiling by array of mouse kidney epithelial cells from pkd1 knockout and wild type in response to fluid flow
Adjusted p-valueLog2-fold change
7.2113 × 10-53.4
Col8a1'infarct and border region of left ventricle 5 days post-myocardial infarction; MRL/MpJ' vs 'left ventricle at baseline (no myocardial infarction) in the same region as the infarct in post-myocardial infarction hearts; MRL/MpJ'clinical information, strainExpression data from C57BL/6J and MRL/MpJ hearts following acute myocardial infarction
Adjusted p-valueLog2-fold change
4.1538 × 10-83.3
Col8a1'Sall4 homozygous knockout' vs 'wild type genotype'genotypeRNA-Seq of Sall4 mutants in mouse embryonic stem cells
Adjusted p-valueLog2-fold change
4.2286 × 10-73.3
Col8a1'oral hard palate epithelium' vs 'tail skin epithelium'organism partTranscriptional profiling of mouse oral and skin epithelium to study their intrinsic difference in global gene expression
Adjusted p-valueLog2-fold change
8.5467 × 10-143.2
Col8a1'undifferentiated' vs 'differentiated; rosiglitazone' in 'A/J'phenotype, stimulus, strainRNA-seq of mouse subcutaneous SVF cells before and after differentiation with a brown fat differentiation cocktail
Adjusted p-valueLog2-fold change
3.1308 × 10-73.2
Col8a1'heart-specific p53 and Mdm2 knockout; 7 day' vs 'heart-specific p53 and Mdm2 knockout; 1 day'phenotype, timeTranscription profiling of heart tissue from mice with heart-specific knockout of p53 and Mdm2
Adjusted p-valueLog2-fold change
9.4544 × 10-53.2
Col8a1'uterine-specific Tsc2-null' vs 'wild type' in '17beta-estradiol'genotype, treatmentTranscription profiling by high throughput sequencing of uterine-specific Tsc2-null mice
Adjusted p-valueLog2-fold change
4.0621 × 10-43.2
Col8a1'unilateral ureteral obstruction' vs 'sham' in 'TIMP3 -/-'genotype, treatmentTIMP2 and TIMP3 have divergent roles in early renal tubulointerstitial injury
Adjusted p-valueLog2-fold change
1.627 × 10-3-3.2
Col8a1'70 week' vs '6 week' in 'none; none;age, irradiatePericyte induced reprogramming of the bone marrow microenvironment drives stem and cancer cell quiescence
Adjusted p-valueLog2-fold change
1.1084 × 10-223
Col8a1'human-Mfn2 T111A/S442A-overexpressing (Mfn2AA)' vs 'tet-off control' in '5 week; left ventricle'age, genotype, organism partTranscription profiling by high throughput sequencing of a mitofusin 2 (Mfn2) mutant in mouse
Adjusted p-valueLog2-fold change
2.1213 × 10-43
Col8a1'ductus arteriosis' vs 'aorta'organism partGene Profiling in Mouse Fetal Ductus Arteriosus
Adjusted p-valueLog2-fold change
4.3835 × 10-43
Col8a1'hepatocyte-derived proliferative ducts (hepPDs)' vs 'biliary-derived proliferative ducts (bilDP)'cell typeTranscription profiling by high throughput sequencing of hepatocyte-derived progenitors cells in a mouse model of oval cell activation
Adjusted p-valueLog2-fold change
1.8469 × 10-33
Col8a1'transforming growth factor beta 1' vs 'none' at '6 day'stimulus, timeExperimental overactivity or blockade of transforming growth factor-B each generate a specific ureter malformation
Adjusted p-valueLog2-fold change
1.2246 × 10-16-2.9
Col8a1'extracellular vesicle; EMT cell culture medium' vs 'none'sampling site, stimulusCellular and extracellular vesicle RNA sequence for E-cadherin-RFP EMT reporter system expressing mouse breast cancer cell line Py2T during EMT/MET
Adjusted p-valueLog2-fold change
7.5623 × 10-112.9
Col8a1'undifferentiated' vs 'differentiated; rosiglitazone' in 'AKR/J'phenotype, stimulus, strainRNA-seq of mouse subcutaneous SVF cells before and after differentiation with a brown fat differentiation cocktail
Adjusted p-valueLog2-fold change
7.2417 × 10-62.9
Col8a1'undifferentiated' vs 'differentiated; rosiglitazone' in '129S6sv/ev'phenotype, stimulus, strainRNA-seq of mouse subcutaneous SVF cells before and after differentiation with a brown fat differentiation cocktail
Adjusted p-valueLog2-fold change
1.1628 × 10-5-2.9
Col8a1'heart-specific Mdm2 knockout; 7 day' vs 'wild type phenotype'phenotype, timeTranscription profiling of heart tissue from mice with heart-specific knockout of p53 and Mdm2
Adjusted p-valueLog2-fold change
4.4807 × 10-32.9
Col8a1'uterine-specific Tsc2-null' vs 'wild type' in 'intact'genotype, treatmentTranscription profiling by high throughput sequencing of uterine-specific Tsc2-null mice
Adjusted p-valueLog2-fold change
4.8739 × 10-32.9
Col8a1'20 day; Ad-VEGF-A164' vs '0 day; control'time, treatmentTranscription profiling by array of stromal-based signatures for the classification of gastric cance
Adjusted p-valueLog2-fold change
1.3351 × 10-8-2.8
Col8a1'6 day; osteogenesis differentiation' vs ' 0 day; control' in '2C12-pMirn0'cell line, growth condition, timeEffect of Mirn378 overexpression on gene expression during C2C12 myogenic and BMP2-induced osteogenic differentiation
Adjusted p-valueLog2-fold change
4.0491 × 10-82.8
Col8a1'clear cell sarcoma; TATCre' vs 'control'disease, genotypeMouse Model of Clear Cell Sarcoma
Adjusted p-valueLog2-fold change
1.643 × 10-5-2.8
Col8a1'heart-specific p53 and Mdm2 knockout; 1 day' vs 'wild type phenotype'phenotype, timeTranscription profiling of heart tissue from mice with heart-specific knockout of p53 and Mdm2
Adjusted p-valueLog2-fold change
4.8635 × 10-2-2.8
Col8a1'neural progenitor cell' vs 'niche cell'cell typeTranscription profiling by high throughput sequencing of three populations of primary dentate gyrus cells
Adjusted p-valueLog2-fold change
1.5065 × 10-112.7
Col8a1'non-infarct region of left ventricle 5 days post-myocardial infarction; MRL/MpJ' vs 'left ventricle at baseline (no myocardial infarction) in the same region as non-infarct tissue in post-myocardial infarction hearts; MRL/MpJ'clinical information, strainExpression data from C57BL/6J and MRL/MpJ hearts following acute myocardial infarction
Adjusted p-valueLog2-fold change
5.2337 × 10-42.7
Col8a1'alphaMHC-Cre+/0;MAT1F/F' vs 'alphaMHC-Cre+/0;MAT1F/+' in '4 week'age, genotypeTranscription profiling of mouse heart from cardiac-specific conditional knockout deletion of menage-a-trios-1 (MAT1)
Adjusted p-valueLog2-fold change
1.1587 × 10-32.7
Col8a1'neuron' vs 'differentiating progenitor'cell typeTranscription profiling by high throughput sequencing of proliferating neural stem cells, differentiating neurogenic progenitors and newborn neurons using a dual-reporter mouse line
Adjusted p-valueLog2-fold change
4.2792 × 10-32.7
Col8a1'Gata6 knockout' vs 'wild type'phenotypeGlobal gene expression in the adult Gata6 null mouse pancreas
Adjusted p-valueLog2-fold change
1.1286 × 10-1262.6
Col8a1'etoposide; 2.5 micromolar' vs 'none' in 'wild type genotype'compound, genotypeRNA-seq of H2afj-ko and isogenic WT C57/Bl6-N mouse embryonic fibroblasts in proliferation and after etoposide-induced senescence.
Adjusted p-valueLog2-fold change
3.2429 × 10-202.6
Col8a1'undifferentiated' vs 'differentiated; rosiglitazone' in 'F1.B6x129'phenotype, stimulus, strainRNA-seq of mouse subcutaneous SVF cells before and after differentiation with a brown fat differentiation cocktail
Adjusted p-valueLog2-fold change
8.8869 × 10-132.6
Col8a1'H-Ras expression; c-Myc activation' vs 'wild type'phenotypeRNA-seq of heart tissue from 15 day old mice 4 hours post MycER activation compared to wild type controls. RNA-seq of heart tissues from adult mice that have expressed oncogenic H-Ras for 4 weeks followed by MycER activation for 4 hours compared to MycER negative controls.
Adjusted p-valueLog2-fold change
5.5738 × 10-72.6
Col8a1'tamoxifen induction at 2 months, wait 6 months' vs 'no tamoxifen induction' in 'basal cell of prostate epithelium; CK5-CreERT2 transgenic line'cell type, genotype, growth conditionTranscription profiling by high throughput sequencing of PIN/tumor lesions from basal or luminal origins at time points at which mice displayed similar histopathological phenotypes
Adjusted p-valueLog2-fold change
2.9803 × 10-62.6
Col8a1'transverse aortic constriction' vs 'sham transverse aortic constriction'treatmentTranscriptional profiling of mouse heat left ventricle after dfferential cardiac remodeling in preload versus afterload.
Adjusted p-valueLog2-fold change
1.3053 × 10-962.5
Col8a1'Irx3 knockout' vs 'control' at '7 day'genetic modification, timeRNA-Seq of mouse Irx3-KO and Control ME3 cells on days 1 and 7 of adipogenic differentiation
Adjusted p-valueLog2-fold change
2.3954 × 10-232.5
Col8a1'CD36 knockout' vs 'wild type genotype' in 'none'compound, genotypeQuantitative analysis of wild type and cd36-/- murine peritoneal macrophage transcriptomes
Adjusted p-valueLog2-fold change
9.0049 × 10-192.5
Col8a1'induced neuronal cell' vs 'pluripotent embryonic stem cell'phenotypeTranscription profiling by high throughput sequencing of retinoic acid-differentiated neuronal cells compared to nondifferentiated pluripotent embryonic stem cells
Adjusted p-valueLog2-fold change
1.7105 × 10-92.5
Col8a1'synovial sarcoma' vs 'control'disease, genotypeMouse Model of Clear Cell Sarcoma
Adjusted p-valueLog2-fold change
2.4989 × 10-72.5
Col8a1'cardiac-specific constitutive expression of an activated Akt (caAkt)' vs 'wild type genotype'genotypeTranscription profiling by array of cardic ventricle tissues from mice with cardiac-specific constitutive expression of an activated Akt (caAkt) and wild-type controls to test whether Akt activation contributes to mitochondrial dysfunction in pathological cardiac hypertrophy
Adjusted p-valueLog2-fold change
1.9992 × 10-52.5
Col8a1'Foxd3 knockout' vs 'control'phenotypeExpression data from embryonic stem cells differentiation
Adjusted p-valueLog2-fold change
2.4812 × 10-5-2.5
Col8a1'heart-specific p53 knockout; 7 day' vs 'wild type phenotype'phenotype, timeTranscription profiling of heart tissue from mice with heart-specific knockout of p53 and Mdm2
Adjusted p-valueLog2-fold change
2.6481 × 10-172.4
Col8a1'undifferentiated' vs 'differentiated; rosiglitazone' in 'F1.129xB6'phenotype, stimulus, strainRNA-seq of mouse subcutaneous SVF cells before and after differentiation with a brown fat differentiation cocktail
Adjusted p-valueLog2-fold change
7.5987 × 10-72.4
Col8a1'CD36 knockout' vs 'wild type genotype' in 'oxidized low density lipoprotein; 25 microgram per milliliter'compound, genotypeQuantitative analysis of wild type and cd36-/- murine peritoneal macrophage transcriptomes
Adjusted p-valueLog2-fold change
2.9798 × 10-22.4
Col8a1'non-infarct region of left ventricle 5 days post-myocardial infarction; C57BL/6J' vs 'left ventricle at baseline (no myocardial infarction) in the same region as non-infarct tissue in post-myocardial infarction hearts; C57BL/6J'clinical information, strainExpression data from C57BL/6J and MRL/MpJ hearts following acute myocardial infarction
Adjusted p-valueLog2-fold change
8.4251 × 10-112.3
Col8a1'wormy, worm separated; Trichuris muris' vs 'control; non wormy' in 'caecum'environmental stress, infect, organism partRNA-seq of mouse intestinal mucosa to investigate infection by the parasitic nematode Trichuris muris
Adjusted p-valueLog2-fold change
4.8258 × 10-5-2.3
Col8a1'heart-specific p53 knockout; 28 day' vs 'wild type phenotype'phenotype, timeTranscription profiling of heart tissue from mice with heart-specific knockout of p53 and Mdm2
Adjusted p-valueLog2-fold change
2.9471 × 10-4-2.3
Col8a1'missense mutation (T2996C) in Mucin 2 (Muc2)' vs 'wild type genotype'genotypeTranscription profiling of mouse intestine in ENU mutagenesis mouse strains with missense mutations in Muc2 mucin and ER stress
Adjusted p-valueLog2-fold change
1.7393 × 10-22.3
Col8a1'5 day; Ad-VEGF-A164' vs '0 day; control'time, treatmentTranscription profiling by array of stromal-based signatures for the classification of gastric cance
Adjusted p-valueLog2-fold change
1.4699 × 10-5-2.2
Col8a1'acute oropharyngeal candidiasis' vs 'healthy' in wild type micecompound, disease, genotype, sexTranscription profiling by array of antibody blockade of IL-17-family cytokines in immunity to acute murine oral mucosal candidiasis
Adjusted p-valueLog2-fold change
2.2946 × 10-42.2
Col8a1'p48-Cre;KrasG12D;Ela-Tgfa' vs 'wild type'genotypeTranscription profiling by array of pancreas from KrasG12D, Ela-Tgfa and KrasG12D Ela-Tgfa mice
Adjusted p-valueLog2-fold change
5.372 × 10-42.2
Col8a1'Insm1-expressing endocrine progenitor cell' vs 'Insm1-lacking endocrine progenitor cell' in 'embryonic day 15.5'cell type, developmental stageTranscriptional regulation of endocrine cell differentiation by Insm1
Adjusted p-valueLog2-fold change
5.2588 × 10-32.2
Col8a1'heart; 3 day' vs 'heart; 0 day'organism part, timeExpression data from mouse tissue Angiotensin II treated for 0,1,3,7days
Adjusted p-valueLog2-fold change
9.1912 × 10-32.2
Col8a1'epithelium-specific Apc knockout' vs 'wild type'phenotypeRNAseq of murine small intestinal tissue following epithelium-specific deletion of Bcl9/9l +/- Apc +/- mutant B-catenin
Adjusted p-valueLog2-fold change
1.1731 × 10-113-2.1
Col8a1'co-cultured with hematopoietic stem cell for 9 days' vs 'non co-cultured for 9 days' in 'endothelial cell; expressing AKT1'cell type, growth condition, phenotypeTranscription profiling by high throughput sequencing of murine bone marrow endothelial cells and bone marrow stroma, in vitro and in vivo, with and without hematopoietic stem cells co-culture
Adjusted p-valueLog2-fold change
1.454 × 10-6-2.1
Col8a1'PF-04691502–resistant cell; 1 micromolar; PF-04691502 removed for 48 hours' vs 'parental AKP cell; dimethyl sulfoxide'compound, phenotypeResistance to PI3K/mTOR inhibitor PF-04691502 in KRAS mutant colorectal cancer models reveals a sensitivity to combination with EGFR inhibition
Adjusted p-valueLog2-fold change
1.0013 × 10-4-2.1
Col8a1'postnatal day 60' vs 'postnatal day 1' in 'insulin-expressing immature beta cell'cell type, developmental stageTranscription profiling by high throughput sequencing of murine beta cells at key stages of maturation
Adjusted p-valueLog2-fold change
3.6739 × 10-42.1
Col8a1'PTEN null' vs 'wild type genotype'genotypeRNA seq of prostate gland from WT, PTEN pc -/- and PTEN pc-/-;P53 -/- mice
Adjusted p-valueLog2-fold change
8.8469 × 10-42.1
Col8a1'tamoxifen induction at 2 months, wait 3 months' vs 'no tamoxifen induction' in 'basal cell of prostate epithelium; CK5-CreERT2 transgenic line'cell type, genotype, growth conditionTranscription profiling by high throughput sequencing of PIN/tumor lesions from basal or luminal origins at time points at which mice displayed similar histopathological phenotypes
Adjusted p-valueLog2-fold change
1.1062 × 10-32.1
Col8a1'apoE knock-out' vs 'wild type'genotypeTranscription profiling by array of aorta from apoE knock-out mice
Adjusted p-valueLog2-fold change
7.7628 × 10-372
Col8a1'etoposide; 2.5 micromolar' vs 'none' in 'H2afj-∆7-KO'compound, genotypeRNA-seq of H2afj-ko and isogenic WT C57/Bl6-N mouse embryonic fibroblasts in proliferation and after etoposide-induced senescence.
Adjusted p-valueLog2-fold change
6.9413 × 10-192
Col8a1'Pkhd1Cre; Pkd2 F/F' vs 'wild type'genotypeNext Generation Sequencing of PKD2 mutant mice kidneys
Adjusted p-valueLog2-fold change
4.1742 × 10-52
Col8a1'cardiotoxin; 40 microliter' vs 'none' in 'wild type' at '12 day'compound, genotype, timeTranscription profiling by array of mouse skeletal muscle expressing CnAa or CnAb1 under the control of the MLC promoter after treatment with cardiotoxin
Adjusted p-valueLog2-fold change
1.7819 × 10-4-2
Col8a1'miR-1-133a_FGFR1_tKO' vs 'miR-1-133a_dKO'compound, genotypeRepression of OSMR and FGFR1 by miR-1/133a prevents adult cardiomyocyte dedifferentiation and cell cycle entry in the adult heart
Adjusted p-valueLog2-fold change
1.3965 × 10-3-2
Col8a1'missense mutation (G9492A) in Mucin 2 (Muc2)' vs 'wild type genotype'genotypeTranscription profiling of mouse intestine in ENU mutagenesis mouse strains with missense mutations in Muc2 mucin and ER stress
Adjusted p-valueLog2-fold change
2.5982 × 10-3-2
Col8a1'miR-1-133a_OSMR_tKO' vs 'miR-1-133a_dKO'compound, genotypeRepression of OSMR and FGFR1 by miR-1/133a prevents adult cardiomyocyte dedifferentiation and cell cycle entry in the adult heart
Adjusted p-valueLog2-fold change
3.741 × 10-32
Col8a1'synovial sarcoma' vs 'normal'diseaseTranscription profiling by array of tumors excised from conditional mouse model of synovial sarcoma compared to skeletal muscle from wild type mice
Adjusted p-valueLog2-fold change
1.3196 × 10-22
Col8a1'unilateral ureteral obstruction' vs 'sham' in 'wild type'genotype, treatmentTIMP2 and TIMP3 have divergent roles in early renal tubulointerstitial injury
Adjusted p-valueLog2-fold change
1.1792 × 10-101.9
Col8a1'Dmd-mdx mutation' vs 'wild type genotype' in 'none'compound, genotypeRNA-seq comparison of fibro-adipogenic progenitors (FAPs) from wild type, mdx and cardiotoxin-injured mice
Adjusted p-valueLog2-fold change
2.7662 × 10-8-1.9
Col8a1'Mycobacterium tuberculosis H37Rv' vs 'none' in 'TNF-alpha knockout'compound, genotype, infect4-week mouse comparative study on effect of neutralizing IL-17A, IL-17F and TNFa antibodies
Adjusted p-valueLog2-fold change
4.585 × 10-8-1.9
Col8a1'MEF; transduced with MyoD lentivirus' vs 'MEF; control'cell line, treatmentGenetic and epigenetic determinants of neurogenesis and myogenesis [expression profiling]
Adjusted p-valueLog2-fold change
5.4753 × 10-41.9
Col8a1'12 day' vs '5 day' in 'doxycycline; 200 nanogram per milliliter; neoplasm'compound, phenotype, timeRNA-seq of doxycycline induced tumor and residual mouse primary mammary epithelial cells grown in 3D cell cultures against non-induced controls
Adjusted p-valueLog2-fold change
1.8806 × 10-31.9
Col8a1'hepatocyte-specific Pten and Tgfbr2 knockout' vs 'wild type'genotypeHepatocyte-specific knockout of Pten and of Pten and Tgfbr2 in mice
Adjusted p-valueLog2-fold change
8.0268 × 10-181.8
Col8a1'brown adipose tissue' vs 'white adipose tissue' in 'high fat diet; 30 degree celsius'diet, organism part, temperatureRNA-seq of brown and white mouse adipose tissue at thermoneutrality and high-fat diet
Adjusted p-valueLog2-fold change
3.1351 × 10-131.8
Col8a1'high fat diet; 30 degree celsius' vs 'chow; 23 degree celsius' in 'brown adipose tissue'diet, organism part, temperatureRNA-seq of brown and white mouse adipose tissue at thermoneutrality and high-fat diet
Adjusted p-valueLog2-fold change
2.8351 × 10-9-1.8
Col8a1'6 day; osteogenesis differentiation' vs ' 0 day; control' in '2C12-pMirn378'cell line, growth condition, timeEffect of Mirn378 overexpression on gene expression during C2C12 myogenic and BMP2-induced osteogenic differentiation
Adjusted p-valueLog2-fold change
3.4188 × 10-91.8
Col8a1'Trichuris muris' vs 'control' in 'non wormy; caecum'environmental stress, infect, organism partRNA-seq of mouse intestinal mucosa to investigate infection by the parasitic nematode Trichuris muris
Adjusted p-valueLog2-fold change
7.326 × 10-7-1.8
Col8a1'5-azacytidine 10 micromolar' vs 'none'compoundTranscription profiling by array of mouse C2C12 cells treated with 5-azacytidine
Adjusted p-valueLog2-fold change
2.7629 × 10-6-1.8
Col8a1'PF-04691502–resistant cell; 1 micromolar; PF-04691502' vs 'parental AKP cell; dimethyl sulfoxide'compound, phenotypeResistance to PI3K/mTOR inhibitor PF-04691502 in KRAS mutant colorectal cancer models reveals a sensitivity to combination with EGFR inhibition
Adjusted p-valueLog2-fold change
9.1793 × 10-51.8
Col8a1'overexpression of CA-NFATc3' vs 'control'phenotypeExpression data from embryonic stem cells differentiation
Adjusted p-valueLog2-fold change
7.4893 × 10-41.8
Col8a1'144 hour after induction of differentiation' vs 'induction of differentiation'compound, sampling time pointExpression Profiling of Early Myogenesis - Affymetrix Dataset
Adjusted p-valueLog2-fold change
1.0046 × 10-21.8
Col8a1'H9; undifferentiated 3factor-reprogrammed induced pluripotent stem cell' vs 'R1; undifferentiated embryonic stem cell' at '0 day'cell line, growth condition, timeNatural cardiogenesis-based template predicts cardiogenic potential of induced pluripotent stem cell lines
Adjusted p-valueLog2-fold change
2.0683 × 10-21.8
Col8a1'TAC surgery' vs 'sham surgery' in 'C57BL/6N'strain, treatmentTranscription profiling of left ventricular myocardium after sham or TAC surgery in BL/6N and BL/6J mice
Adjusted p-valueLog2-fold change
5.1985 × 10-13-1.7
Col8a1'Trp53 knockout' vs 'wild type genotype' in 'dimethyl sulfoxide; 0.1 microliter'compound, phenotypeResidual tumor suppressor activities of tumorigenic p53 mutants enhance survival under chemotherapy
Adjusted p-valueLog2-fold change
1.1646 × 10-91.7
Col8a1'Cnot3 knockout' vs 'wild type'phenotypeRNA-seq of mouse islets from Ins1-cre driven Cnot3 KO and control islets
Adjusted p-valueLog2-fold change
1.5942 × 10-81.7
Col8a1'wormy, worm left; Trichuris muris' vs 'control; non wormy' in 'caecum'environmental stress, infect, organism partRNA-seq of mouse intestinal mucosa to investigate infection by the parasitic nematode Trichuris muris
Adjusted p-valueLog2-fold change
6.3506 × 10-71.7
Col8a1'epithelium-specific Apc; Bcl9; Bcl9l knockout' vs 'wild type'phenotypeRNAseq of murine small intestinal tissue following epithelium-specific deletion of Bcl9/9l +/- Apc +/- mutant B-catenin
Adjusted p-valueLog2-fold change
6.528 × 10-6-1.7
Col8a1'5,9-endoperoxy-cholest-7-en-3β,6α-diol' vs 'vehicle (cyclodextrin)'compound, timeArray results for differential gene expression in 661W, a mouse cone photoreceptor-derived cell line, comparing cells incubated with vehicle controls vs. those treated with either of two 7-dehdyrocholesterol-derived oxysterols or cholesterol
Adjusted p-valueLog2-fold change
5.4786 × 10-51.7
Col8a1'transverse aortic constriction' vs 'sham surgery' at '10 day'clinical treatment, timeTranscription profiling of mouse gene expression after transverse aortic constriction in mice: comparison of TAC vs. sham group at 2, 10 and 21 days to identify the differential expression of genes
Adjusted p-valueLog2-fold change
1.2506 × 10-31.7
Col8a1'heart; 7 day' vs 'heart; 0 day'organism part, timeExpression data from mouse tissue Angiotensin II treated for 0,1,3,7days
Adjusted p-valueLog2-fold change
5.4466 × 10-31.7
Col8a1'aortic banding' at '168 hour' vs 'sham' at '168 hour'injury, timeTranscription profiling of heart ventricles from mice at different time points after surgical intervention for pressure-overload induced hypertrophy to identify differentially expressed genes.
Adjusted p-valueLog2-fold change
5.611 × 10-31.7
Col8a1'neurosphere in differentiation medium; 12 day' vs 'neurosphere; 0 day' in 'Cstb knockout'genotype, growth condition, timeTranscriptome analysis of neurospheres derived from Cstb-KO mouse embryo brains during differentiation
Adjusted p-valueLog2-fold change
5.8051 × 10-3-1.7
Col8a1'APP/APLP2 double conditional knockout' vs 'control'genotypeTranscriptional Profiling of Neuronal APP/APLP2 Double-Conditional Knockout Mice.
Adjusted p-valueLog2-fold change
2.7948 × 10-19-1.6
Col8a1'Trp53 knockout' vs 'wild type genotype' in 'Nutlin-3a; 10 micromolar'compound, phenotypeResidual tumor suppressor activities of tumorigenic p53 mutants enhance survival under chemotherapy
Adjusted p-valueLog2-fold change
5.1164 × 10-151.6
Col8a1'Pkhd1Cre; Pkd2 F/F; miR-21null' vs 'wild type'genotypeNext Generation Sequencing of PKD2 mutant mice kidneys
Adjusted p-valueLog2-fold change
7.2896 × 10-81.6
Col8a1'10 day' vs '0 day'ageTranscription profiling of mouse embyronic stem cell line CGR8 during the first 10 days of differentiation into embryoid bodies
Adjusted p-valueLog2-fold change
2.2749 × 10-51.6
Col8a1'M-27; over-expressing IGF-IR' vs 'M-27; wild type'cell line, genotypeTranscription profiling of wild_type and IGF-I receptor over-expressing mouse lung carcinoma cells identifies a type I insulin like growth factor receptor regulated gene expression profile associated with an altered site-specificity of metastasis.
Adjusted p-valueLog2-fold change
2.2329 × 10-41.6
Col8a1'undifferentiated' vs 'differentiated; rosiglitazone' in 'SWR/J'phenotype, stimulus, strainRNA-seq of mouse subcutaneous SVF cells before and after differentiation with a brown fat differentiation cocktail
Adjusted p-valueLog2-fold change
5.1716 × 10-41.6
Col8a1'H-Ras expression' vs 'wild type'phenotypeRNA-seq of heart tissue from 15 day old mice 4 hours post MycER activation compared to wild type controls. RNA-seq of heart tissues from adult mice that have expressed oncogenic H-Ras for 4 weeks followed by MycER activation for 4 hours compared to MycER negative controls.
Adjusted p-valueLog2-fold change
2.1324 × 10-31.6
Col8a1'unilateral ureteral obstruction' vs 'sham' in 'TIMP2 -/-'genotype, treatmentTIMP2 and TIMP3 have divergent roles in early renal tubulointerstitial injury
Adjusted p-valueLog2-fold change
2.7115 × 10-3-1.6
Col8a1'stabilization-competent' vs 'stabilization-incompetent' in '23 day; secondary reprogramming cell'age, cell type, phenotypeTranscription profiling by high throughput sequencing in gene expresion profile of 4 SC clones and 4 SI clones at different time points defined a stabilization competency signiture
Adjusted p-valueLog2-fold change
1.0627 × 10-2-1.6
Col8a1'total RNA; HRasV12 and c-Myc overexpression and Eif4e wild type' vs 'total RNA; wild type'fraction, genotypeRedefining the role of eIF4E dose in development, cancer, and protein synthesis
Adjusted p-valueLog2-fold change
3.9969 × 10-2-1.6
Col8a1'polysomal RNA; HRasV12 and c-Myc overexpression and Eif4e wild type' vs 'polysomal RNA; wild type'fraction, genotypeRedefining the role of eIF4E dose in development, cancer, and protein synthesis
Adjusted p-valueLog2-fold change
3.3775 × 10-91.5
Col8a1'S-(1,2-dichlorovinyl)-L-cysteine; 15 milligram per kilogram; renal injury; 1 week' vs 'none; normal'compound, disease, timeExpression profiling experiment on Pkd1-mutant mice and mice induced with nephrotoxin DCVC
Adjusted p-valueLog2-fold change
9.7191 × 10-8-1.5
Col8a1'doxycycline-induced expression of NGN3' vs 'control' at '48 hour'time, treatmentTranscription profiling by array of mouse embryonic stem cells expressing the transcription factor NGN3 for 12 hours, 24 hours and 48 hours
Adjusted p-valueLog2-fold change
6.4782 × 10-71.5
Col8a1'gamma radiation; 8 Gray' vs 'none' in 'Lgr5-Cre-ERT2'genotype, irradiateRNA Seq of colonic Lgr5+ epithelial stem cells in Il22+/+ and Il22-/- mice during homeostasis and 24h after irradiation with 8 Gy
Adjusted p-valueLog2-fold change
2.4438 × 10-61.5
Col8a1'SR-BI-/- apoE-/-' vs 'control' in '43 day; Chow diet'age, diet, genotypeExpression data from the hearts of a mouse model of spontaneous myocardial infarction
Adjusted p-valueLog2-fold change
2.7072 × 10-5-1.5
Col8a1'Alk5 fl/fl; Wnt1-Cre' vs 'control'genotypeGene expression profiling of the tongue bud from Alk5 mutant mouse models
Adjusted p-valueLog2-fold change
4.7862 × 10-5-1.5
Col8a1'4 week' vs '0 week'timeTranscription profiling by array of mouse colon tissues with T cell transfer-induced colitis at week 0, 2, 4 and 6 post-transfer
Adjusted p-valueLog2-fold change
7.1035 × 10-4-1.5
Col8a1'Drosha -/-' vs 'wild type genotype'genotypeRNA-seq of mouse ES cells with conditional Drosha knockout against wild type controls to identify pri-miRNAs
Adjusted p-valueLog2-fold change
3.0393 × 10-3-1.5
Col8a1'extracellular vesicle; non-stimulated culture medium' vs 'none'sampling site, stimulusCellular and extracellular vesicle RNA sequence for E-cadherin-RFP EMT reporter system expressing mouse breast cancer cell line Py2T during EMT/MET
Adjusted p-valueLog2-fold change
6.1487 × 10-31.5
Col8a1'aortic banding' at '48 hour' vs 'sham' at '48 hour'injury, timeTranscription profiling of heart ventricles from mice at different time points after surgical intervention for pressure-overload induced hypertrophy to identify differentially expressed genes.
Adjusted p-valueLog2-fold change
9.6996 × 10-31.5
Col8a1'neurogenin-3-expressing endocrine progenitor cell' vs 'neurogenin-3-lacking pancreatic progenitor cell' at 'embryonic day 15.5'cell type, developmental stageTranscription profiling by high throughput sequencing of murine beta cells at key stages of maturation
Adjusted p-valueLog2-fold change
2.0223 × 10-2-1.5
Col8a1'APP/APLP2 double conditional knockout' vs 'APP knockout'genotypeTranscriptional Profiling of Neuronal APP/APLP2 Double-Conditional Knockout Mice.
Adjusted p-valueLog2-fold change
3.9815 × 10-21.5
Col8a1'undifferentiated' vs 'differentiated; rosiglitazone' in 'C57BL/6J'phenotype, stimulus, strainRNA-seq of mouse subcutaneous SVF cells before and after differentiation with a brown fat differentiation cocktail
Adjusted p-valueLog2-fold change
6.4039 × 10-101.4
Col8a1'phenylephrine; 30 milligram per kilogram per day' vs 'vehicle'compoundRNA-seq of myocytes from mice treated in vivo for 3 days with vehicle, angiotensin II, or phenylephrine
Adjusted p-valueLog2-fold change
1.1504 × 10-81.4
Col8a1'nmf205, Gcn2 double mutant' vs 'wild type'genotypeTranscription profiling by high throughput sequencing in cerebellum of mouse Gcn2 -/-, nmf205-/- and nmf205-/-;Gcn2-/-
Adjusted p-valueLog2-fold change
3.7492 × 10-5-1.4
Col8a1'oxidized low density lipoprotein; 25 microgram per milliliter' vs 'none' in 'CD36 knockout'compound, genotypeQuantitative analysis of wild type and cd36-/- murine peritoneal macrophage transcriptomes
Adjusted p-valueLog2-fold change
5.7282 × 10-5-1.4
Col8a1'SARS coronavirus MA15 dORF6' vs 'none' at '2 day'infect, timeSM012 - SARS MA15 wild type, and SARS deltaORF6 mutant virus infections of C57BL6 mice - A time course
Adjusted p-valueLog2-fold change
1.0925 × 10-4-1.4
Col8a1'6 week' vs '0 week'timeTranscription profiling by array of mouse colon tissues with T cell transfer-induced colitis at week 0, 2, 4 and 6 post-transfer
Adjusted p-valueLog2-fold change
1.5388 × 10-4-1.4
Col8a1'left ventricle' vs 'right ventricle' in 'embryonic day 9.5'developmental stage, organism partTranscriptional Atlas of Cardiogenesis Maps Congenital Heart Disease Interactome
Adjusted p-valueLog2-fold change
2.7581 × 10-41.4
Col8a1'postnatal >1 year; hindlimb' vs 'embryonic day 17.5; whole forelimb and hindlimb'age, organism partExpression data from skeletal muscle satellite cells at different development stages
Adjusted p-valueLog2-fold change
6.2271 × 10-31.4
Col8a1'Irs gene knockout' vs 'wild type genotype'genotypeTranscription profiling of mouse brown preadipocytes from wild type and IRS knock-out cell lines
Adjusted p-valueLog2-fold change
1.417 × 10-2-1.4
Col8a1'APP/APLP2 double conditional knockout' vs 'APLP2 knockout'genotypeTranscriptional Profiling of Neuronal APP/APLP2 Double-Conditional Knockout Mice.
Adjusted p-valueLog2-fold change
3.2215 × 10-21.4
Col8a1'heterozygous dn-p21ras' vs 'wild type'genotypeTranscription profiling of heart ventricles from 10 week old mice heterozygous for dn-p21ras and 3 month old wild type FVB mice to study severe dilated cardiomyopathy.
Adjusted p-valueLog2-fold change
6.0718 × 10-8-1.3
Col8a1'SARS coronavirus MA15; 2 day' vs 'mock' in 'WSB/EiJ'infect, strain, timeGenomic profiling of collaborative cross founder mouse strains infected with respiratory viruses to discover novel transcripts and infection-related strain-specific gene and isoform expression
Adjusted p-valueLog2-fold change
8.5688 × 10-6-1.3
Col8a1'CXCR3 knockout; SARS MA15; 2 day' vs 'CXCR3 knockout; mock'genotype, infect, timeInfection of wild type and CXCR3 knockout C57BL6/J mice with SARS MA15
Adjusted p-valueLog2-fold change
4.3142 × 10-5-1.3
Col8a1'dinitrofluorobenzene' vs 'control' in 'wild type'compound, genotypeTranscription profiling of mouse Cannabinoid receptor double knockouts (Cnr1 -/- /Cnr2 -/-) in CHS model to investigate cutaneous contact hypersensitivity
Adjusted p-valueLog2-fold change
8.2677 × 10-5-1.3
Col8a1'Mycobacterium tuberculosis; DBA/2J congenic; 70 day' vs 'control; DBA/2J congenic; 0 day'infect, strain, timeTranscription profiling of mouse lung from C57BL6 and DBA2 parental strains and D2.B6-Chr7 and D2.B6-Chr19 congenic mice following aerosol infection with Mycobacterium tuberculosis for 30 and 70 days
Adjusted p-valueLog2-fold change
6.2154 × 10-41.3
Col8a1'10 day' vs '0 day'ageTime course analysis of the cardiac transcriptome in the neonatal period
Adjusted p-valueLog2-fold change
1.941 × 10-31.3
Col8a1'anti-IL-17A and anti-IL-17F treatment' vs 'no treatment' in 'wild type mice with acute oropharyngeal candidiasis'compound, disease, genotype, sexTranscription profiling by array of antibody blockade of IL-17-family cytokines in immunity to acute murine oral mucosal candidiasis
Adjusted p-valueLog2-fold change
2.9638 × 10-3-1.3
Col8a1'reduced expression of miR-25' vs 'wild type'phenotypeTranscription profiling by high throughput sequencing of wild type and miR-25 agomir or antagomir treated mice
Adjusted p-valueLog2-fold change
3.3447 × 10-3-1.3
Col8a1'UO126; 0.2 milligram per kilogram; miR-1-133a_dKO' vs 'miR-1-133a_dKO'compound, genotypeRepression of OSMR and FGFR1 by miR-1/133a prevents adult cardiomyocyte dedifferentiation and cell cycle entry in the adult heart
Adjusted p-valueLog2-fold change
5.5202 × 10-31.3
Col8a1'transverse aortic constriction' vs 'sham surgery' at '21 day'clinical treatment, timeTranscription profiling of mouse gene expression after transverse aortic constriction in mice: comparison of TAC vs. sham group at 2, 10 and 21 days to identify the differential expression of genes
Adjusted p-valueLog2-fold change
1.6474 × 10-21.3
Col8a1'Mettl6 knockout clone G6' vs 'wild type genotype'genotypeMETTL6 is a tRNA m3C methyltransferase that regulates translation and tumor cell proliferation
Adjusted p-valueLog2-fold change
1.9387 × 10-21.3
Col8a1'Mettl6 knockout clone D1' vs 'wild type genotype'genotypeMETTL6 is a tRNA m3C methyltransferase that regulates translation and tumor cell proliferation
Adjusted p-valueLog2-fold change
8.8732 × 10-261.2
Col8a1'cut nerve; 7 day' vs 'none'injury, protocol, timeChanges in the coding/non-coding transcriptome and DNA methylome that define the Schwann cell repair phenotype after nerve injury
Adjusted p-valueLog2-fold change
1.5056 × 10-10-1.2
Col8a1'Mycobacterium tuberculosis H37Rv' vs 'none' in 'wild type'compound, genotype, infect4-week mouse comparative study on effect of neutralizing IL-17A, IL-17F and TNFa antibodies
Adjusted p-valueLog2-fold change
2.8949 × 10-8-1.2
Col8a1'MG132; 1 micromolar' vs 'DMSO' in 'CHOP-/-'compound, genotypeMicroarray to find CHOP dependent genes in response to proteasome inhibition
Adjusted p-valueLog2-fold change
3.9941 × 10-81.2
Col8a1'mdx/mdx' vs 'wild type'genotypeTranscription profiling by array of mdx mouse gastrocnemius muscle
Adjusted p-valueLog2-fold change
7.2958 × 10-8-1.2
Col8a1'3 day; myogenesis differentiation' vs ' 0 day; control' in '2C12-pMirn378'cell line, growth condition, timeEffect of Mirn378 overexpression on gene expression during C2C12 myogenic and BMP2-induced osteogenic differentiation
Adjusted p-valueLog2-fold change
8.9269 × 10-8-1.2
Col8a1'SARS coronavirus MA15; 2 day' vs 'mock' in 'C57BL/6J'infect, strain, timeGenomic profiling of collaborative cross founder mouse strains infected with respiratory viruses to discover novel transcripts and infection-related strain-specific gene and isoform expression
Adjusted p-valueLog2-fold change
1.3545 × 10-6-1.2
Col8a1'3 day; osteogenesis differentiation' vs ' 0 day; control' in '2C12-pMirn378'cell line, growth condition, timeEffect of Mirn378 overexpression on gene expression during C2C12 myogenic and BMP2-induced osteogenic differentiation
Adjusted p-valueLog2-fold change
4.8684 × 10-6-1.2
Col8a1'mutant MyoD expression' at '24 hour' vs 'control' at '24 hour'phenotype, timeTranscription profiling of mouse embryoic fibroblasts expressing wild type MyoD or its non-acetylatable version MyoD RRR to investigate how MyoD acetylation may contribute to differential gene activation.
Adjusted p-valueLog2-fold change
1.2674 × 10-51.2
Col8a1'ko cyld-/-' vs 'wild type'genotypeTranscription profiling by array of mouse liver with Cyld inactivation
Adjusted p-valueLog2-fold change
1.5882 × 10-5-1.2
Col8a1'chronic cystitis' vs 'none' in 'C57/Bl6'disease, strainChronic cystitis microarray comparing C3H/HeN and C57BL/6 bladder gene expression
Adjusted p-valueLog2-fold change
1.6366 × 10-51.2
Col8a1'CDK4/6 inhibitor PD 0332991' vs 'vehicle'compoundGene expression profile of mouse breast cancer V720 cells treated with vehicle or PD 0332991
Adjusted p-valueLog2-fold change
9.6252 × 10-5-1.2
Col8a1'Mycobacterium tuberculosis; DBA/2J congenic; 30 day' vs 'control; DBA/2J congenic; 0 day'infect, strain, timeTranscription profiling of mouse lung from C57BL6 and DBA2 parental strains and D2.B6-Chr7 and D2.B6-Chr19 congenic mice following aerosol infection with Mycobacterium tuberculosis for 30 and 70 days
Adjusted p-valueLog2-fold change
1.7064 × 10-4-1.2
Col8a1'adipogenic' vs 'non-adipogenic'phenotypeTranscription profiling by array of mouse sublines of Swiss 3T3 fibroblasts with varying potential for adipogenesis
Adjusted p-valueLog2-fold change
1.8903 × 10-4-1.2
Col8a1'extracellular vesicle; MET cell culture medium' vs 'none'sampling site, stimulusCellular and extracellular vesicle RNA sequence for E-cadherin-RFP EMT reporter system expressing mouse breast cancer cell line Py2T during EMT/MET
Adjusted p-valueLog2-fold change
2.4826 × 10-4-1.2
Col8a1'21 percent oxygen, 37 degree Celsius, no serum' vs 'none'growth conditionRNA sequencing of native and ex vivo cultured murine tail tendon fascicles
Adjusted p-valueLog2-fold change
7.0718 × 10-41.2
Col8a1'high fat diet' vs 'normal chow' in '28 week; ReverbαFlox2-6AdipoCre-'age, diet, genotypeTissue-autonomous regulation of adipose expansion by core clock protein REVERBα
Adjusted p-valueLog2-fold change
1.4083 × 10-31.2
Col8a1'tumor' vs 'normal' in 'kidney'clinical information, organism partPremature termination of in vivo reprogramming leads to cancer development through altered epigenetic regulation [array]
Adjusted p-valueLog2-fold change
2.1285 × 10-31.2
Col8a1'colitis' at '8 day' vs 'normal' at '0 day'disease, timeTemporal transcriptomic changes during DSS colitis development and resolution.
Adjusted p-valueLog2-fold change
2.2106 × 10-31.2
Col8a1'cardiotoxin; 10 micromolar' vs 'none' in 'wild type genotype'compound, genotypeRNA-seq comparison of fibro-adipogenic progenitors (FAPs) from wild type, mdx and cardiotoxin-injured mice
Adjusted p-valueLog2-fold change
2.6179 × 10-3-1.2
Col8a1'SARS coronavirus MA15; 2 day' vs 'mock' in 'PWK/PhJ'infect, strain, timeGenomic profiling of collaborative cross founder mouse strains infected with respiratory viruses to discover novel transcripts and infection-related strain-specific gene and isoform expression
Adjusted p-valueLog2-fold change
3.9046 × 10-31.2
Col8a1'anti-IL-17F treatment' vs 'no treatment' in wild type mice with acute oropharyngeal candidiasiscompound, disease, genotype, sexTranscription profiling by array of antibody blockade of IL-17-family cytokines in immunity to acute murine oral mucosal candidiasis
Adjusted p-valueLog2-fold change
4.8164 × 10-31.2
Col8a1'96 hour after induction of differentiation' vs 'induction of differentiation'compound, sampling time pointExpression Profiling of Early Myogenesis - Affymetrix Dataset
Adjusted p-valueLog2-fold change
5.2463 × 10-3-1.2
Col8a1'dextran sodium sulphate induced colitis' vs 'normal' in 'L-Arginine'compound, diseaseTranscription profiling by array of murine colon tissue after exposure to 4% dextran sodium sulphate (DSS) for 6 days followed by 4 days of water or 1% L-arginine to study the effect of L-arginine on DSS-induced colitis
Adjusted p-valueLog2-fold change
5.7173 × 10-31.2
Col8a1'transplanted secondary tumors' vs 'normal' in 'kidney'clinical information, organism partPremature termination of in vivo reprogramming leads to cancer development through altered epigenetic regulation [array]
Adjusted p-valueLog2-fold change
6.6547 × 10-31.2
Col8a1'mutant MyoD expression' at '24 hour' vs 'wild type MyoD expression' at '24 hour'phenotype, timeTranscription profiling of mouse embryoic fibroblasts expressing wild type MyoD or its non-acetylatable version MyoD RRR to investigate how MyoD acetylation may contribute to differential gene activation.
Adjusted p-valueLog2-fold change
9.9652 × 10-3-1.2
Col8a1'total RNA; HRasV12 and c-Myc overexpression and Eif4e heterozygous knockout' vs 'total RNA; wild type'fraction, genotypeRedefining the role of eIF4E dose in development, cancer, and protein synthesis
Adjusted p-valueLog2-fold change
1.2079 × 10-21.2
Col8a1'miR-1-133a_dKO' vs 'wild type genotype'compound, genotypeRepression of OSMR and FGFR1 by miR-1/133a prevents adult cardiomyocyte dedifferentiation and cell cycle entry in the adult heart
Adjusted p-valueLog2-fold change
1.6616 × 10-2-1.2
Col8a1'SARS coronavirus MA15; 10^4 PFU' vs 'none' at '2 day'stimulus, timeSM001: SARS CoV MA15 infection of C57Bl/6 mouse model – Data from 4 viral doses at 1, 2, 4 and 7 days post infection.
Adjusted p-valueLog2-fold change
1.7909 × 10-21.2
Col8a1'TAC surgery' vs 'sham surgery' in 'C57BL/6J'strain, treatmentTranscription profiling of left ventricular myocardium after sham or TAC surgery in BL/6N and BL/6J mice
Adjusted p-valueLog2-fold change
4.6882 × 10-2-1.2
Col8a1'SARS coronavirus MA15; 10^5 PFU' vs 'none' at '2 day'stimulus, timeSM001: SARS CoV MA15 infection of C57Bl/6 mouse model – Data from 4 viral doses at 1, 2, 4 and 7 days post infection.
Adjusted p-valueLog2-fold change
3.1552 × 10-8-1.1
Col8a1'Pbx1 -/-; Pbx2 -/-' vs 'wild type genotype' at '12 hour'genotype, timeRNA-seq of wild-type, Pbx1/Pbx2 double-knockout and pMsgn1-mut EpiSCs differentiated in vitro to pre-somitic mesoderm in the first 24 hours of differentiation.
Adjusted p-valueLog2-fold change
3.4845 × 10-61.1
Col8a1'5-aza-2'-deoxycytidine; 5 micromolar' vs 'none'compoundTranscription profiling by array of mouse primary dermal fibroblasts after treatment with 5-aza-2'-deoxycytidine
Adjusted p-valueLog2-fold change
8.5546 × 10-5-1.1
Col8a1'dinitrofluorobenzene' vs 'control' in 'Cnr1 -/- /Cnr2 -/-'compound, genotypeTranscription profiling of mouse Cannabinoid receptor double knockouts (Cnr1 -/- /Cnr2 -/-) in CHS model to investigate cutaneous contact hypersensitivity
Adjusted p-valueLog2-fold change
2.8756 × 10-4-1.1
Col8a1'tape stripping' vs 'control'treatmentTranscription profiling by array of mouse dorsal skin after tape stripping and treatment with winged bean extract.
Adjusted p-valueLog2-fold change
5.9454 × 10-4-1.1
Col8a1'chemical hypoxia' vs 'control'growth conditionComparison of gene expression in whole blood of mice subjected to chemical hypoxia in vivo.
Adjusted p-valueLog2-fold change
1.0756 × 10-3-1.1
Col8a1'Mycobacterium tuberculosis; D2.B6-Chr7 congenic; 70 day' vs 'control; D2.B6-Chr7 congenic; 0 day'infect, strain, timeTranscription profiling of mouse lung from C57BL6 and DBA2 parental strains and D2.B6-Chr7 and D2.B6-Chr19 congenic mice following aerosol infection with Mycobacterium tuberculosis for 30 and 70 days
Adjusted p-valueLog2-fold change
1.3819 × 10-31.1
Col8a1'osteoblast culture 9 day' vs '0 day'timeTranscription profiling by array of mouse primary neonatal osteoblasts to study the regulation of bone mineralisation
Adjusted p-valueLog2-fold change
2.3287 × 10-3-1.1
Col8a1'Wnt1Cre Ezh2lox/lox' vs 'control'genotypeExpression data from E11.5 mouse branchial arch 1 (BA1) - comparison between Ezh2lox/lox and Wnt1Cre Ezh2lox/lox embryos
Adjusted p-valueLog2-fold change
4.3327 × 10-31.1
Col8a1'Gata4+/-' vs 'wild type genotype' in 'TAC-mediated heart pressure overload'environmental stress, genotypeTranscription profiling of hearts from mice heterozygous for Gata4 mutation (G4D) to investigate the significance of Gata4 in regulating postnatal heart function and in regulating the hypertrophic response of the heart to pathological stress.
Adjusted p-valueLog2-fold change
1.3191 × 10-2-1.1
Col8a1'acute DSS-induced colitis; 1x DSS, no recovery' vs 'none; none'clinical treatment, diseaseTranscription profiling by array of colon tissues isolated from mice with acute and chronic dextran sodium sulphate (DSS)-induced colitis
Adjusted p-valueLog2-fold change
1.5625 × 10-21.1
Col8a1'overexpression of SRC-2' vs 'control'phenotypeA pivotal role of SRC-2 in Metastatic and Castration Resistant Prostate Cancer
Adjusted p-valueLog2-fold change
1.6581 × 10-21.1
Col8a1'Adipo-SIRT1' vs 'wild type genotype' in 'Ad libitum; 40 week'age, diet, genotypeGene expression analysis of adipose tissues from WT, Adipo-SIRT1 and Adipo-H363Y mice
Adjusted p-valueLog2-fold change
4.5957 × 10-21.1
Col8a1'TLR3 knockout' vs 'wild type genotype' in 'SARS coronavirus MA15' at '4 day'genotype, infect, timeMouse lung tissue transcriptome response to a mouse-adapted strain of SARS-CoV in wild type C57BL6/NJ mice and TLR3-/- mice
Adjusted p-valueLog2-fold change
9.4704 × 10-9-1
Col8a1'Psen 1 and 2 null' vs 'wild type'genotypeQuantitative Analysis of Notch mutant (Notch1&2-null, Psen1&2-null, RBPjk-null) and wild-type hair follicle transcriptomes by NGS
Adjusted p-valueLog2-fold change
8.5246 × 10-6-1
Col8a1'wild type; SARS MA15; 2 day' vs 'wild type; mock'genotype, infect, timeInfection of wild type and CXCR3 knockout C57BL6/J mice with SARS MA15
Adjusted p-valueLog2-fold change
1.3505 × 10-4-1
Col8a1'500 micromolar palmitate' vs '1 volume percent bovine serum albumin'compoundTranscription profiling of mouse C2C12 myotubes treated overnight with 500 uM palmitate or 1% bovine serum albumin control to identify mediators of obesity-linked reductions in PGC-1
Adjusted p-valueLog2-fold change
1.9604 × 10-4-1
Col8a1'West Nile virus; late stage encephalitis' vs 'mock infection'infect, timeTranscriptomic profiling of the brains of WNV and CHIKV infection-induced encephalitis in young mice after 2, 3 or 5 days post infection
Adjusted p-valueLog2-fold change
2.8685 × 10-4-1
Col8a1'Apc knockout in Villin1 positive cells' vs 'wild type'phenotypeTranscription profiling by array of Apc-deficient proximal colonic epithelium upon Msx1 transcription factor depletion
Adjusted p-valueLog2-fold change
3.4758 × 10-4-1
Col8a1'SARS coronavirus MA15; 10^3 PFU' vs 'none' at '4 day'stimulus, timeSM001: SARS CoV MA15 infection of C57Bl/6 mouse model – Data from 4 viral doses at 1, 2, 4 and 7 days post infection.
Adjusted p-valueLog2-fold change
3.586 × 10-4-1
Col8a1'resolved cystitis' vs 'none' in 'C57/Bl6'disease, strainChronic cystitis microarray comparing C3H/HeN and C57BL/6 bladder gene expression
Adjusted p-valueLog2-fold change
4.0863 × 10-41
Col8a1'hyperoxia' vs 'control' in 'male'sex, stimulusTranscription profiling by array of lung tissues from wild-type male and female C56BL/6J mice either maintained in room air or exposed to hyperoxia (FiO2>95%) for 48 hours
Adjusted p-valueLog2-fold change
5.5165 × 10-41
Col8a1'phosgene - carbonyl chloride' at '24 hour' vs 'air' at '24 hour'compound, timeTranscription profiling of lung from mouse exposed to carbonyl chloride (phosgene) for different lengths of time to investigate the molecular mechanism of phosgene-induced lung injury
Adjusted p-valueLog2-fold change
8.5676 × 10-41
Col8a1'gamma radiation; 8 Gray' vs 'none' in 'Lgr5-Cre-ERT2; Il22-/-'genotype, irradiateRNA Seq of colonic Lgr5+ epithelial stem cells in Il22+/+ and Il22-/- mice during homeostasis and 24h after irradiation with 8 Gy
Adjusted p-valueLog2-fold change
1.1042 × 10-31
Col8a1'phosgene - carbonyl chloride' at '24 hour' vs 'none' at '0 hour'compound, timeTranscription profiling of lung from mouse exposed to carbonyl chloride (phosgene) for different lengths of time to investigate the molecular mechanism of phosgene-induced lung injury
Adjusted p-valueLog2-fold change
1.9986 × 10-31
Col8a1'Yin Yang 1 (YY1) knockout' vs 'wild type'genotypeExpression data from mouse skeletal muscle
Adjusted p-valueLog2-fold change
2.1133 × 10-31
Col8a1'osteoblast culture 27 day' vs '0 day'timeTranscription profiling by array of mouse primary neonatal osteoblasts to study the regulation of bone mineralisation
Adjusted p-valueLog2-fold change
3.3537 × 10-31
Col8a1'Abcc8-/-' vs 'wild type genotype' in 'high fat; male'diet, genotype, sexEffects of increased intracellular calcium and overnutrition on pancreatic beta cell transcriptome
Adjusted p-valueLog2-fold change
3.8212 × 10-31
Col8a1'Sdhb knockout' vs 'wild type'genotype, phenotypeGene expression analysis of SDH-deficient immortalized mouse kidney epithelial cells
Adjusted p-valueLog2-fold change
4.8894 × 10-31
Col8a1'Ezh2f/f;Mef2cAHF::Cre knockout' vs 'Ezh2f/f wild type'genotypeTranscription profiling by array of mouse heart mutant for Ezh2
Adjusted p-valueLog2-fold change
6.2292 × 10-31
Col8a1'Meis1; Meis2 conditional knockout' vs 'wild type phenotype'phenotypeMeis homeobox genes control cell competence within the eye-specified neuroepithelium (RNA-seq)
Adjusted p-valueLog2-fold change
6.2382 × 10-31
Col8a1'CD2AP-/-' vs 'wild type genotype' in 'renal glomerular mesangial cell'cell type, genotypeTranscription profiling by array of three major cell types of the glomerulus (podocytes, mesangial cells and endothelial cells) from CD2AP-/- mutant mice and normal controls
Adjusted p-valueLog2-fold change
6.4709 × 10-31
Col8a1'Setd5 homozygous (null) knockout' vs 'Setd5 heterozygous knockout'genotypeTranscriptional profiling of Setd5 heterozygous and knockout mouse embryonic stem cells
Adjusted p-valueLog2-fold change
7.1715 × 10-3-1
Col8a1'high fat' vs 'chow' in 'WSB/EiJ'diet, strainTranscription profiling by high throughput sequencing of a Diversity Outbred mice population and the eight founder strains: A/J, 129S1/SvImJ, C57BL/6J, NOD/ShiLtJ, NZO/HlLtJ, CAST/EiJ, PWK/PhJ, and WSB/EiJ
Adjusted p-valueLog2-fold change
7.2309 × 10-3-1
Col8a1'RAW264.7 macrophage cell line; control' vs 'bone marrow macrophage; control'cell type, growth conditionTranscription profiling of mouse bone marrow macrophages (BMM) compared to BMM co-cultured with 4T1.2 breast cancer cells, treated with tumour cell supernatant, or RAW macrophage cell line
Adjusted p-valueLog2-fold change
7.9604 × 10-3-1
Col8a1'chronic DSS-induced colitis; 2x DSS, recovery' vs 'none; none'clinical treatment, diseaseTranscription profiling by array of colon tissues isolated from mice with acute and chronic dextran sodium sulphate (DSS)-induced colitis
Adjusted p-valueLog2-fold change
9.747 × 10-3-1
Col8a1'carcinoma' vs 'normal'diseaseGene expression profile between normal mouse skin and carcinomas arising in the skin of RbF/F;K14creERTM;p107-/- mouse
Adjusted p-valueLog2-fold change
1.0891 × 10-2-1
Col8a1'doxorubicin; 17.5 milligram per kilogram body weight' vs 'vehicle' in 'scramble; podocyte'cell type, compound, genotypeTranscription profiling to identify the role of MOF in primary MEFs and differentiated podocytes in response to Adriamycin
Adjusted p-valueLog2-fold change
1.121 × 10-2-1
Col8a1'chronic DSS-induced colitis; 1x DSS, recovery' vs 'none; none'clinical treatment, diseaseTranscription profiling by array of colon tissues isolated from mice with acute and chronic dextran sodium sulphate (DSS)-induced colitis
Adjusted p-valueLog2-fold change
1.3592 × 10-21
Col8a1'none; ; CHIP knockout' vs 'none; ; wild type'compound, genotypeExpression data from DOX(doxorubicin) -treated wild type or CHIP knockout C57BL/6J mice at day 5
Adjusted p-valueLog2-fold change
1.4003 × 10-21
Col8a1'heart; 1 day' vs 'heart; 0 day'organism part, timeExpression data from mouse tissue Angiotensin II treated for 0,1,3,7days
Adjusted p-valueLog2-fold change
1.9789 × 10-21
Col8a1'Abcc8-/-' vs 'wild type genotype' in 'normal; male'diet, genotype, sexEffects of increased intracellular calcium and overnutrition on pancreatic beta cell transcriptome
Adjusted p-valueLog2-fold change
2.5937 × 10-21
Col8a1'Reg3beta knockout' vs 'wild type' in 'tissue from remote zone'clinical information, genotypemyocardial infarction in Reg3beta knock-out mice
Adjusted p-valueLog2-fold change
3.0188 × 10-21
Col8a1'CD47 knockdown; endothelial’ vs 'wild type; endothelial'cell line, cell type, genotypeCD47 Inhibits Self-renewal and Reprogramming by Regulating c-Myc and Other Stem Cell Transcription Factors
Adjusted p-valueLog2-fold change
3.3868 × 10-21
Col8a1'15 day' vs '0 day'ageTime course analysis of the cardiac transcriptome in the neonatal period
Adjusted p-valueLog2-fold change
4.9043 × 10-21
Col8a1'Smad4f/f x CCSPicrePtenf/f' vs 'wild type' at '12 month'age, genotypeErbB2 Pathway Activation upon Smad4 Loss Promotes Lung Tumor Growth and Metastasis [expression]
Synonym
Col8a-1
Ortholog
Gene ontology
InterPro
Ensembl gene
Ensembl transcript
Ensembl protein
Entrez
UniProt
MGI ID (Mouse)
MGI description
Gene biotype
Design element
10440091, 1455627_at, Msa.2740.0_at, 4804938, 5555810, A_52_P292792, 5394259, 4752693, 4863995, 5400882, 4706520, 1418441_at, 4809008, 5172259, 4476988, 5157493, 17331162, A_52_P282058, ILMN_2503553, 5330353, 4958851, 4764362, 4570390, 5502059, 5198847, 100308_at, 5294470, 4661762, A_52_P184855, 5281420, 1418440_at, 5476507, 4788459, 5196078, 5041311, 4652693
Reactome pathway ID