Details of EBI-54574280

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Interaction Details

Accession
EBI-54574280
Type
association
Detection Method
anti tag coip
Host Organism
Homo sapiens HEK293T embryonic kidney cell
Positive Interaction
✔️
External Cross References (1)
DatabaseIdentifier
doi 10.1016/j.cell.2021.04.011
Annotations (7)
TopicDescription
data-processing Unique baits available for UniProt mapping = 8897 Bad mapping (2/< gene IDs mapping to single Uniprot) = 11 Ambiguous baits = 14 Remaining imported = 8872
curation depth imex curation
figure legend Supplementary table 1
data-processing Authors' have stated that bait-prey pairs was filtered according to CompPASS-Plus score: "interactions with an interaction score equal to or greater than 0.75 were retained to create the final interaction network. This cutoff of 0.75 corresponds to the top ~2% of candidate interactions in both 293T and HCT116 cells. Interactions observed in 293T and HCT116 networks are summarized in Tables S1B and S1D, respectively" - We considered Tables S1B and S1D for our import.
data-processing 103 interactors do not have valid protein sequences; one interactor has non-discernable UniProt IDs | #Gene ID 445815 = fusion protein PALM2 and AKAP2 = should be considered as single entry UniProtKB: Q9Y2D5) | Replace Gene IDs 114299 & 11217 to 445815
accepted Accepted 2024-MAY-16 AT 08:04 BST AT 08:04 BST by ORCHARD
data-processing Q8N655 - merged with Q96JN0 | Gene ID Name UniProt Ac "8263 F8A1 P23610" "474383 F8A2. P23610" "203611 CDY2B Q9Y6F7" "9426 CDY2A Q9Y6F7" "8339 HIST1H2BG P62807" "8344 HIST1H2BE P62807" "8346 HIST1H2BI P62807" | "8350 HIST1H3A P68431" "8352 HIST1H3C P68431" "8353 HIST1H3E P68431" "8354 HIST1H3I P68431" "8355 HIST1H3G P68431" "8356 HIST1H3J P68431" "8358 HIST1H3B P68431" "8968 HIST1H3F P68431 "8294 HIST1H4I P62805" "8359 HIST1H4A P62805" "8361 HIST1H4F P62805" "8362 HIST1H4K P62805" "8366 HIST1H4B P62805" "8368 HIST1H4L P62805" "407977 TNFSF12-TNFSF13 O43508" "8742 TNFSF12 O43508" These baits/interactions were not captured

Publication

Title
Dual proteome-scale networks reveal cell-specific remodeling of the human interactome.
Journal
Cell
Authors
Huttlin EL.,Bruckner RJ.,Navarrete-Perea J.,Cannon JR.,Baltier K.,Gebreab F.,Gygi MP.,Thornock A.,Zarraga G.,Tam S.,Szpyt J.,Gassaway BM.,Panov A.,Parzen H.,Fu S.,Golbazi A.,Maenpaa E.,Stricker K.,Guha Thakurta S.,Zhang T.,Rad R.,Pan J.,Nusinow DP.,Paulo JA.,Schweppe DK.,Vaites LP.,Harper JW.,Gygi SP.
Publication date
01/01/2021
Publication reference
PubMed: 33961781
External Cross References (1)
DatabaseIdentifier
imex
Annotations (1)
TopicDescription
contact-email edward_huttlin@hms.harvard.edu,wade_harper@hms.harvard.edu