Interaction Viewer

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Interaction Details

Accession
EBI-2515634
Detection Method
anti tag coip
Positive Interaction
✔️
External Cross References (2)
DatabaseIdentifier
imex
psi-mi MI:0469
Annotations (8)
TopicDescription
curation depth imex curation
accepted Accepted 2010-FEB-6 by ORCHARD.
figure legend submitted by author
curation request Harper Wade: 28th Oct 2009, Department of Pathology, Harvard Medical School, 77 Avenue Louis Pasteur, NRB 940, Boston, MA 02115
author-announcement 23-Feb-2010: Contacted by JYOTI.
last-imex-assigned 100
reviewer orchard
confidence-mapping Interactors scored using the D score which incorporates the uniqueness, the abundance of the interactor (TSC), and the reproducibility of the interaction to assign a score to each protein within each IP (the same protein in two different IPs may have distinct D scores since its TSC and reproducibility could differ). In this way, the highest scores are given to proteins in each IP that are found rarely, found in duplicate runs, and have high TSCs-all characteristics of proteins that would be considered candidate interactors. A global D score threshold (DT) is determined and all raw D scores (DR) are normalized to this value, producing DN scores.

Publication

Title
Defining the Human Deubiquitinating Enzyme Interaction Landscape
Journal
Cell (0092-8674)
Authors
Sowa ME.,Bennett EJ.,Gygi SP.,Harper JW.
Publication date
01/01/2009
Publication reference
PubMed: 19615732
External Cross References (1)
DatabaseIdentifier
imex
Annotations (1)
TopicDescription
contact-email wade_harper@hms.harvard.edu,mathew_sowa@hms.harvard.edu