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EMBL

was set up in 1974 as Europe’s flagship laboratory for the life sciences – an intergovernmental organisation with more than 80 independent research groups covering the spectrum of molecular biology:

Research:

perform basic research in molecular biology

Services:

offer vital services to scientists in the member states

Training

scientists, students and visitors at all levels

Transfer

and development of technology

Develop

new instruments and methods

Integrating

life science research in Europe

More about EMBL

Six sites

represent EMBL in Europe.

Barcelona

Tissue biology and disease modelling

Grenoble

Structural biology

Hamburg

Structural biology

Heidelberg

Main laboratory

Hinxton

EMBL-EBI: European Bioinformatics Institute

Rome

Epigenetics and neurobiology

Search for id:EBI-297353 AND id:EBI-519884

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Interaction Network

Legend

Nodes

Color ~ Species

Homo sapiens

Shape ~ Type

protein

Edges

Color ~ MI Score

Width ~ #Evidence

Showing 1 to 10 of 10 entries

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Select	Molecule A	Molecule B	Identifier A	Identifier B	Type A	Type B	Species A	Species B	Host Organism	Positive interaction	Detection Method	Publication IDs	Interaction Type	Interaction AC	Confidence Value	Expansion Method	Aliases A	Aliases B	Feature count	Interaction Annotations

Select	Molecule A	Molecule B	Identifier A	Identifier B	Type A	Type B	Species A	Species B	Host Organism	Positive interaction	Detection Method	Publication IDs	Interaction Type	Interaction AC	Confidence Value	Expansion Method	Aliases A	Aliases B	Feature count	Interaction Annotations
Show details of EBI-25466126	BBC3	EGFR	UniProt Q9BXH1	UniProt P00533	protein	protein	Homo sapiens	Homo sapiens	Homo sapiens D-270MG glioblastoma cell	✔️	anti bait coip	20153921	physical association	EBI-25466126	MI Score:0.4		gene name synonym PUMA gene name synonym p53 up-regulated modulator of apoptosis gene name synonym JFY-1 gene name BBC3	gene name synonym Proto-oncogene c-ErbB-1 gene name synonym HER1 gene name synonym Receptor tyrosine-protein kinase erbB-1 gene name EGFR gene name synonym ERBB gene name synonym ERBB1	1	figure legend 1C
Show details of EBI-25466581	BBC3	EGFR	UniProt Q9BXH1	UniProt P00533	protein	protein	Homo sapiens	Homo sapiens	Homo sapiens D-317 MG glioma cell	✔️	anti bait coip	20153921	physical association	EBI-25466581	MI Score:0.4		gene name synonym PUMA gene name synonym p53 up-regulated modulator of apoptosis gene name synonym JFY-1 gene name BBC3	gene name synonym Proto-oncogene c-ErbB-1 gene name synonym HER1 gene name synonym Receptor tyrosine-protein kinase erbB-1 gene name EGFR gene name synonym ERBB gene name synonym ERBB1	1	figure legend 1C
Show details of EBI-25466629	BBC3	EGFR	UniProt Q9BXH1	UniProt P00533	protein	protein	Homo sapiens	Homo sapiens	Homo sapiens UWR1/MGR1 astrocytoma cell	✔️	anti bait coip	20153921	physical association	EBI-25466629	MI Score:0.4		gene name synonym PUMA gene name synonym p53 up-regulated modulator of apoptosis gene name synonym JFY-1 gene name BBC3	gene name synonym Proto-oncogene c-ErbB-1 gene name synonym HER1 gene name synonym Receptor tyrosine-protein kinase erbB-1 gene name EGFR gene name synonym ERBB gene name synonym ERBB1	1	figure legend 1D
Show details of EBI-25466663	BBC3	EGFR	UniProt Q9BXH1	UniProt P00533	protein	protein	Homo sapiens	Homo sapiens	Homo sapiens U-87 MG glioblastoma cell	✔️	anti bait coip	20153921	physical association	EBI-25466663	MI Score:0.4		gene name synonym PUMA gene name synonym p53 up-regulated modulator of apoptosis gene name synonym JFY-1 gene name BBC3	gene name synonym Proto-oncogene c-ErbB-1 gene name synonym HER1 gene name synonym Receptor tyrosine-protein kinase erbB-1 gene name EGFR gene name synonym ERBB gene name synonym ERBB1	0	figure legend 4
Show details of EBI-25466687	BBC3	EGFR	UniProt Q9BXH1	UniProt P00533	protein	protein	Homo sapiens	Homo sapiens	Homo sapiens T98G caucasian glioblastoma cell	✔️	anti bait coip	20153921	physical association	EBI-25466687	MI Score:0.4		gene name synonym PUMA gene name synonym p53 up-regulated modulator of apoptosis gene name synonym JFY-1 gene name BBC3	gene name synonym Proto-oncogene c-ErbB-1 gene name synonym HER1 gene name synonym Receptor tyrosine-protein kinase erbB-1 gene name EGFR gene name synonym ERBB gene name synonym ERBB1	0	comment PUMA primarily interacts with the EGFR protein that is not associated with plasma membranes. figure legend 4, Supp. fig 2.
Show details of EBI-25466718	BBC3	EGFR	UniProt Q9BXH1	UniProt P00533	protein	protein	Homo sapiens	Homo sapiens	Homo sapiens U-87 MG glioblastoma cell	✔️	anti bait coip	20153921	physical association	EBI-25466718	MI Score:0.4		gene name synonym PUMA gene name synonym p53 up-regulated modulator of apoptosis gene name synonym JFY-1 gene name BBC3	gene name synonym Proto-oncogene c-ErbB-1 gene name synonym HER1 gene name synonym Receptor tyrosine-protein kinase erbB-1 gene name EGFR gene name synonym ERBB gene name synonym ERBB1	1	figure legend 1C, 4
Show details of EBI-25466725	BBC3	EGFR	UniProt Q9BXH1	UniProt P00533	protein	protein	Homo sapiens	Homo sapiens	Homo sapiens U-87 MG glioblastoma cell	✔️	anti bait coip	20153921	physical association	EBI-25466725	MI Score:0.4		gene name synonym PUMA gene name synonym p53 up-regulated modulator of apoptosis gene name synonym JFY-1 gene name BBC3	gene name synonym Proto-oncogene c-ErbB-1 gene name synonym HER1 gene name synonym Receptor tyrosine-protein kinase erbB-1 gene name EGFR gene name synonym ERBB gene name synonym ERBB1	1	comment Auto-phosphorylated EGFR (p-EGFR, Y1068/Y1092) was seen only in the presence of EGF. figure legend 4, 6A/B remark-internal Cell signalling ( supplier) provide no info on pTyr residue. comment Info regarding "p1068" was found on the Abcam website:-(Antibody)Recognises EGFR phosphorylated on Tyrosine 1068 of the mature human isoform 1 (corresponding to Y1092 from the precursor form P00533-1/p170)
Show details of EBI-25466773	BBC3	EGFR	UniProt Q9BXH1	UniProt P00533	protein	protein	Homo sapiens	Homo sapiens	Homo sapiens T98G caucasian glioblastoma cell	✔️	anti bait coip	20153921	physical association	EBI-25466773	MI Score:0.4		gene name synonym PUMA gene name synonym p53 up-regulated modulator of apoptosis gene name synonym JFY-1 gene name BBC3	gene name synonym Proto-oncogene c-ErbB-1 gene name synonym HER1 gene name synonym Receptor tyrosine-protein kinase erbB-1 gene name EGFR gene name synonym ERBB gene name synonym ERBB1	0	comment PUMA primarily interacts with the EGFR protein that is not associated with plasma membranes. source-text PUMA primarily interacts with the EGFR protein that is not associated with plasma membranes. figure legend Supp. fig 2.
Show details of EBI-25597470	BBC3	EGFR	UniProt Q9BXH1	UniProt P00533	protein	protein	Homo sapiens	Homo sapiens	Homo sapiens UWR2/MGR2 astrocytoma cell	✔️	anti bait coip	20153921	physical association	EBI-25597470	MI Score:0.4		gene name synonym PUMA gene name synonym p53 up-regulated modulator of apoptosis gene name synonym JFY-1 gene name BBC3	gene name synonym Proto-oncogene c-ErbB-1 gene name synonym HER1 gene name synonym Receptor tyrosine-protein kinase erbB-1 gene name EGFR gene name synonym ERBB gene name synonym ERBB1	1	figure legend 1D
Show details of EBI-25597498	BBC3	EGFR	UniProt Q9BXH1	UniProt P00533	protein	protein	Homo sapiens	Homo sapiens	Homo sapiens UWR3/MGR3 astrocytoma cell	✔️	anti bait coip	20153921	physical association	EBI-25597498	MI Score:0.4		gene name synonym PUMA gene name synonym p53 up-regulated modulator of apoptosis gene name synonym JFY-1 gene name BBC3	gene name synonym Proto-oncogene c-ErbB-1 gene name synonym HER1 gene name synonym Receptor tyrosine-protein kinase erbB-1 gene name EGFR gene name synonym ERBB gene name synonym ERBB1	1	figure legend 1D

Showing 1 to 10 of 10 entries

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Showing 1 to 2 of 2 entries

Select	Accession	Name	Preferred ID	Type	Species	Description	Alias	Alternative IDs	Interactions found in current search	Total interactions in all IntAct
	EBI-297353	EGFR	UniProt P00533	protein	Homo sapiens	Epidermal growth factor receptor	gene name synonym Proto-oncogene c-ErbB-1 gene name synonym HER1 gene name synonym Receptor tyrosine-protein kinase erbB-1 gene name EGFR gene name synonym ERBB gene name synonym ERBB1	UniProt14 Q9UMD8 Q9H3C9 Q9H2C9 Q9UMD7 Q9GZX1 O00688 Q9BZS2 O00732 P00533 Q9UMG5 Q14225 P06268 Q92795 Q68GS5 Ensembl1 ENSP00000275493.2 IntAct2 EBI-297353 EBI-28985169	2	2067
	EBI-1307	PAK1	UniProt Q13153	protein	Homo sapiens	Serine/threonine-protein kinase PAK 1	gene name synonym Alpha-PAK gene name synonym p65-PAK gene name synonym p21-activated kinase 1 gene name PAK1	UniProt6 Q32M54 Q32M53 Q13567 Q13153 Q86W79 O75561 IntAct2 EBI-28976107 EBI-1307 Ensembl1 ENSP00000348696.4	2	426

Showing 1 to 2 of 2 entries