D
IPR000118

Granulin

InterPro entry
Short nameGranulin
Overlapping
homologous
superfamilies
 

Description

Metazoan granulins
[1]
are a family of cysteine-rich peptides of about 6 Kd which may have multiple biological activity. A precursor protein (known as acrogranin) potentially encodes seven different forms of granulin (grnA to grnG) which are probably released by post-translational proteolytic processing. Granulins are evolutionary related to PMP-D1, a peptide extracted from the pars intercerebralis of migratory locusts
[2]
. A schematic representation of the structure of a granulin is shown below:

       xxxCxxxxxCxxxxxCCxxxxxxxxCCxxxxxxCCxxxxxCCxxxxxCxxxxxxCx

'C': conserved cysteine probably involved in a disulphide bond.

In plants a granulin domain is often associated with the C terminus of cysteine proteases belong to the MEROPS peptidase family C1, subfamily C1A (papain).

References

1.Isolation and sequence of the granulin precursor cDNA from human bone marrow reveals tandem cysteine-rich granulin domains. Bhandari V, Palfree RG, Bateman A. Proc. Natl. Acad. Sci. U.S.A. 89, 1715-9, (1992). View articlePMID: 1542665

2.Isolation and structural determination of three peptides from the insect Locusta migratoria. Identification of a deoxyhexose-linked peptide. Nakakura N, Hietter H, Van Dorsselaer A, Luu B. Eur. J. Biochem. 204, 147-53, (1992). View articlePMID: 1740125

Cross References

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