D
IPR000352

Peptide chain release factor class I

InterPro entry
Short namePep_chain_release_fac_I
Overlapping
homologous
superfamilies
 

Description

Peptide chain release factors (RFs) are required for the termination of protein biosynthesis
[1]
. At present two classes of RFs can be distinguished. Class I RFs bind to ribosomes that have encountered a stop codon at their decoding site and induce release of the nascent polypeptide. Class II RFs are GTP-binding proteins that interact with class I RFs and enhance class I RF activity. In prokaryotes there are two class I RFs that act in a codon specific manner
[2]
: RF-1(gene prfA) mediates UAA and UAG-dependent termination while RF-2 (gene prfB) mediates UAA and UGA-dependent termination. RF-1 and RF-2 are structurally and evolutionary related proteins which have been shown to be part of a larger family
[3]
.

References

1.Hidden infidelities of the translational stop signal. Tate WP, Poole ES, Mannering SA. Prog. Nucleic Acid Res. Mol. Biol. 52, 293-335, (1996). PMID: 8821264

2.Recent advances in peptide chain termination. Craigen WJ, Lee CC, Caskey CT. Mol. Microbiol. 4, 861-5, (1990). View articlePMID: 2215213

3.Sequence comparison of new prokaryotic and mitochondrial members of the polypeptide chain release factor family predicts a five-domain model for release factor structure. Pel HJ, Rep M, Grivell LA. Nucleic Acids Res. 20, 4423-8, (1992). View articlePMID: 1408743

GO terms

cellular component

  • None

Cross References

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