D
IPR000566

Lipocalin/cytosolic fatty-acid binding domain

InterPro entry
Short nameLipocln_cytosolic_FA-bd_dom
Overlapping
homologous
superfamilies
 
Calycin (IPR012674)
domain relationships

Description

This entry represents the lipocalin/cytosolic fatty-acid binding domain of a group of proteins that belong to the calycin superfamily.

Proteins which transport small hydrophobic molecules such as steroids, bilins, retinoids, and lipids share limited regions of sequence homology and a common tertiary structure architecture
[1, 2, 3, 4, 5]
. This is an eight stranded antiparallel β-barrel with a repeated + 1 topology enclosing a internal ligand binding site
[4, 3]
. The name 'lipocalin' has been proposed
[1]
for this protein family, but cytosolic fatty-acid binding proteins are also included. The sequences of most members of the family, the core or kernal lipocalins, are characterised by three short conserved stretches of residues, while others, the outlier lipocalin group, share only one or two of these
[6, 4]
. Proteins known to belong to this family include alpha-1-microglobulin (protein HC); alpha-1-acid glycoprotein (orosomucoid)
[7]
; aphrodisin; apolipoprotein D; beta-lactoglobulin; complement component C8 gamma chain
[8]
; crustacyanin
[9]
; epididymal-retinoic acid binding protein (E-RABP)
[10]
; insectacyanin; odorant-binding protein (OBP); human pregnancy-associated endometrial alpha-2 globulin; probasin (PB), a rat prostatic protein; prostaglandin D synthase (
5.3.99.2
)
[11]
; purpurin; Von Ebner's gland protein (VEGP)
[12]
; and lizard epididymal secretory protein IV (LESP IV)
[13]
.

References

1.Homology and structure-function correlations between alpha 1-acid glycoprotein and serum retinol-binding protein and its relatives. Pervaiz S, Brew K. FASEB J. 1, 209-14, (1987). View articlePMID: 3622999

2.Structural organization of the gene for prostaglandin D synthase in the rat brain. Igarashi M, Nagata A, Toh H, Urade Y, Hayaishi O. Proc. Natl. Acad. Sci. U.S.A. 89, 5376-80, (1992). View articlePMID: 1608945

3.Crystallographic refinement of human serum retinol binding protein at 2A resolution. Cowan SW, Newcomer ME, Jones TA. Proteins 8, 44-61, (1990). View articlePMID: 2217163

4.Structure and sequence relationships in the lipocalins and related proteins. Flower DR, North AC, Attwood TK. Protein Sci. 2, 753-61, (1993). View articlePMID: 7684291

5.The structural motif of beta-lactoglobulin and retinol-binding protein: a basic framework for binding and transport of small hydrophobic molecules? Godovac-Zimmermann J. Trends Biochem. Sci. 13, 64-6, (1988). View articlePMID: 3238752

6.Mouse oncogene protein 24p3 is a member of the lipocalin protein family. Flower DR, North AC, Attwood TK. Biochem. Biophys. Res. Commun. 180, 69-74, (1991). View articlePMID: 1834059

7.Drug binding to human alpha-1-acid glycoprotein in health and disease. Kremer JM, Wilting J, Janssen LH. Pharmacol. Rev. 40, 1-47, (1988). View articlePMID: 3064105

8.Structural and functional characterization of complement C8 gamma, a member of the lipocalin protein family. Haefliger JA, Peitsch MC, Jenne DE, Tschopp J. Mol. Immunol. 28, 123-31, (1991). View articlePMID: 1707134

9.Complete sequence and model for the A2 subunit of the carotenoid pigment complex, crustacyanin. Keen JN, Caceres I, Eliopoulos EE, Zagalsky PF, Findlay JB. Eur. J. Biochem. 197, 407-17, (1991). View articlePMID: 2026162

10.Structure of the epididymal retinoic acid binding protein at 2.1 A resolution. Newcomer ME. Structure 1, 7-18, (1993). View articlePMID: 8069623

11.The first lipocalin with enzymatic activity. Peitsch MC, Boguski MS. Trends Biochem. Sci. 16, 363, (1991). View articlePMID: 1723819

12.Structural organization of the genes for rat von Ebner's gland proteins 1 and 2 reveals their close relationship to lipocalins. Kock K, Ahlers C, Schmale H. Eur. J. Biochem. 221, 905-16, (1994). View articlePMID: 7514123

13.LESP, an androgen-regulated lizard epididymal secretory protein family identified as a new member of the lipocalin superfamily. Morel L, Dufaure JP, Depeiges A. J. Biol. Chem. 268, 10274-81, (1993). View articlePMID: 8486691

Cross References

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