F
IPR000600

ROK family

InterPro entry
Short nameROK
Overlapping
homologous
superfamilies
 
family relationships

Description

A family of bacterial proteins has been described which groups transcriptional repressors, sugar kinases and yet uncharacterised open reading frames
[1]
. This family, known as ROK (Repressor, ORF, Kinase) includes the xylose operon repressor, xylR, from Bacillus subtilis, Lactobacillus pentosus and Staphylococcus xylosus; N-acetylglucosamine repressor, nagC, from Escherichia coli; glucokinase
2.7.1.2
from Streptomyces coelicolor; fructokinase
2.7.1.4
from Pediococcus pentosaceus, Streptococcus mutans and Zymomonas mobilis; allokinase
2.7.1.55
and mlc from E. coli; and E. coli hypothetical proteins yajF and yhcI and the corresponding Haemophilus influenzae proteins. The repressor proteins (xylR and nagC) from this family possess an N-terminal region not present in the sugar kinases and which contains an helix-turn-helix DNA-binding motif.

References

1.Evolutionary relationships between sugar kinases and transcriptional repressors in bacteria. Titgemeyer F, Reizer J, Reizer A, Saier MH Jr. Microbiology (Reading, Engl.) 140 ( Pt 9), 2349-54, (1994). PMID: 7952186

Cross References

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