IPR000768
NAD:arginine ADP-ribosyltransferase, ART
InterPro entry
Short name | ART |
family relationships |
Description
Mono-ADP-ribosylation is a post-translational modification of proteins in which the ADP-ribose moiety of NAD is transferred to proteins. This process is responsible for the toxicity of some bacterial toxins (e.g., cholera and pertussis toxins). Mono (ADP-ribosyl) transferases exist in vertebrates
2.4.2.31 that transfer ADP-ribose to arginine
[1, 3, 4].
NAD+ + L-arginine = nicotinamide + N2-(ADP-D-ribosyl)-L-arginine
At least five forms of the enzyme have been characterised to date, some of which are attached to the membrane via glycosylphosphatidylinositol (GPI) anchors, while others appear to be secreted. The enzymes contain ~250-300 residues, which encode putative signal sequences and carbohydrate attachment sites. In addition, the N- and C-termini are predominantly hydrophobic, a characteristic of GPI-anchored proteins
[2].
References
1.Cloning and characterization of a novel membrane-associated lymphocyte NAD:arginine ADP-ribosyltransferase. Okazaki IJ, Kim HJ, Moss J. J. Biol. Chem. 271, 22052-7, (1996). View articlePMID: 8703012
2.Immunological and structural conservation of mammalian skeletal muscle glycosylphosphatidylinositol-linked ADP-ribosyltransferases. Okazaki IJ, Zolkiewska A, Nightingale MS, Moss J. Biochemistry 33, 12828-36, (1994). View articlePMID: 7947688
GO terms
biological process
- None
molecular function
cellular component
- None
Cross References
Representative structure
6dre: ADP-ribosyltransferase toxin/immunity pair