F
IPR000768

NAD:arginine ADP-ribosyltransferase, ART

InterPro entry
Short nameART
family relationships

Description

Mono-ADP-ribosylation is a post-translational modification of proteins in which the ADP-ribose moiety of NAD is transferred to proteins. This process is responsible for the toxicity of some bacterial toxins (e.g., cholera and pertussis toxins). Mono (ADP-ribosyl) transferases exist in vertebrates
2.4.2.31
that transfer ADP-ribose to arginine
[1, 3, 4]
.

NAD+ + L-arginine = nicotinamide + N2-(ADP-D-ribosyl)-L-arginine

At least five forms of the enzyme have been characterised to date, some of which are attached to the membrane via glycosylphosphatidylinositol (GPI) anchors, while others appear to be secreted. The enzymes contain ~250-300 residues, which encode putative signal sequences and carbohydrate attachment sites. In addition, the N- and C-termini are predominantly hydrophobic, a characteristic of GPI-anchored proteins
[2]
.

References

1.Cloning and characterization of a novel membrane-associated lymphocyte NAD:arginine ADP-ribosyltransferase. Okazaki IJ, Kim HJ, Moss J. J. Biol. Chem. 271, 22052-7, (1996). View articlePMID: 8703012

2.Immunological and structural conservation of mammalian skeletal muscle glycosylphosphatidylinositol-linked ADP-ribosyltransferases. Okazaki IJ, Zolkiewska A, Nightingale MS, Moss J. Biochemistry 33, 12828-36, (1994). View articlePMID: 7947688

3.ADP-ribosylation at R125 gates the P2X7 ion channel by presenting a covalent ligand to its nucleotide binding site. Adriouch S, Bannas P, Schwarz N, Fliegert R, Guse AH, Seman M, Haag F, Koch-Nolte F. FASEB J 22, 861-9, (2008). PMID: 17928361

4.Glucagon like-peptide-1 receptor is covalently modified by endogenous mono-ADP-ribosyltransferase. Dezelak M, Bavec A. Mol Biol Rep 39, 4375-81, (2012). PMID: 21901419

GO terms

biological process

  • None

cellular component

  • None

Cross References

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