F
IPR000837

AP-1 transcription factor

InterPro entry
Short nameAP-1

Description

The transcription factor activator protein (AP)-1 consists of Jun (c-Jun, JunB, and JunD), Fos (c-Fos, FosB, Fra1, and Fra2), ATF and JDP family members
[1]
. They are basic leucine zipper transcription factors that play a central role in regulating gene transcription in various biological processes
[3]
. This entry includes Fos, ATF-3 and JDP family members.

AP-1 proteins have an α-helical bZIP domain, which contains a basic DNA-binding region and regularly spaced leucine residues known as the leucine zipper motif
[2]
. They have similar protein structure and can either form homodimers or form heterodimers with other AP-1 proteins (predominantly with Jun proteins), which can then bind to TRE-like sequences (consensus sequence 5'-TGAG/CTCA-3')
[1]
. Each of these proteins are expressed in different tissues and can be regulated in different ways, which means that every cell type has a complex mixture of AP-1 dimers with subtly different functions
[1]
.

References

1.AP-1 subunits: quarrel and harmony among siblings. Hess J, Angel P, Schorpp-Kistner M. J. Cell. Sci. 117, 5965-73, (2004). View articlePMID: 15564374

2.Specificity through cooperation: BATF-IRF interactions control immune-regulatory networks. Murphy TL, Tussiwand R, Murphy KM. Nat. Rev. Immunol. 13, 499-509, (2013). View articlePMID: 23787991

3.Role and regulation of activator protein-1 in toxicant-induced responses of the lung. Reddy SP, Mossman BT. Am. J. Physiol. Lung Cell Mol. Physiol. 283, L1161-78, (2002). PMID: 12424143

GO terms

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