D
IPR000999

Ribonuclease III domain

InterPro entry
Short nameRNase_III_dom
Overlapping
homologous
superfamilies
 

Description

This domain is found in eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease
[5, 1]
. Prokaryotic RNAse III is important in post-transcriptional control of mRNA stability and translational efficiency. It is involved in the processing of ribosomal RNA precursors. Prokaryotic RNAse III also plays a role in the maturation of tRNA precursors and in the processing of phage and plasmid transcripts. Eukaryotic RNase III's participate (through direct cleavage) in rRNA processing, in processing of small nucleolar RNAs (snoRNAs) and snRNA's (components of the spliceosome). In eukaryotes RNase III or RNaseIII like enzymes such as Dicer are involved in RNAi (RNA interference) and miRNA (micro-RNA) gene silencing
[3, 2, 4]
.

References

1.Noncatalytic assembly of ribonuclease III with double-stranded RNA. Blaszczyk J, Gan J, Tropea JE, Court DL, Waugh DS, Ji X. Structure 12, 457-66, (2004). View articlePMID: 15016361

2.Dicers at RISC; the mechanism of RNAi. Tijsterman M, Plasterk RH. Cell 117, 1-3, (2004). View articlePMID: 15066275

3.RNase III enzymes and the initiation of gene silencing. Carmell MA, Hannon GJ. Nat. Struct. Mol. Biol. 11, 214-8, (2004). View articlePMID: 14983173

4.Ribonuclease III: new sense from nuisance. Conrad C, Rauhut R. Int. J. Biochem. Cell Biol. 34, 116-29, (2002). View articlePMID: 11809414

5.Crystallographic and modeling studies of RNase III suggest a mechanism for double-stranded RNA cleavage. Blaszczyk J, Tropea JE, Bubunenko M, Routzahn KM, Waugh DS, Court DL, Ji X. Structure 9, 1225-36, (2001). View articlePMID: 11738048

GO terms

biological process

cellular component

  • None

Cross References

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