IPR001025
Bromo adjacent homology (BAH) domain
InterPro entry
Short name | BAH_dom |
Overlapping homologous superfamilies |
Description
The BAH (bromo-adjacent homology) is commonly found in chromatin-associated proteins
[1]. It is found in proteins such as eukaryotic DNA (cytosine-5) methyltransferases
IPR001525, the origin recognition complex 1 (Orc1) proteins, as well as several proteins involved in transcriptional regulation. The BAH domain appears to act as a protein-protein interaction module specialised in gene silencing, as suggested for example by its interaction within yeast Orc1p with the silent information regulator Sir1p. The BAH module might therefore play an important role by linking DNA methylation, replication and transcriptional regulation
[2].
References
1.The BAH domain of Rsc2 is a histone H3 binding domain. Chambers AL, Pearl LH, Oliver AW, Downs JA. Nucleic Acids Res. 41, 9168-82, (2013). View articlePMID: 23907388
2.The BAH (bromo-adjacent homology) domain: a link between DNA methylation, replication and transcriptional regulation. Callebaut I, Courvalin JC, Mornon JP. FEBS Lett. 446, 189-93, (1999). View articlePMID: 10100640
GO terms
Cross References
Representative structure
8ds8: Crystal structure of human TNRC18 BAH domain in complex with H3K9me3 peptide