IPR001034
DeoR-type HTH domain
InterPro entry
Short name | DeoR_HTH |
Overlapping homologous superfamilies |
Description
The deoR-type HTH domain is a DNA-binding, helix-turn-helix (HTH) domain ofvabout 50-60 amino acids present in transcription regulators of the deoR family, involved in sugar catabolism. This family of prokaryotic regulators is named after the Escherichia coli protein DeoR, a repressor of the deo operon, which encodes nucleotide and deoxyribonucleotide catabolic enzymes. DeoR also negatively regulates the expression of nupG and tsx, a nucleoside-specific transport protein and a channel-forming protein, respectively.
DeoR-like transcription repressors occur in diverse bacteria as regulators of sugar and nucleoside metabolic systems. The effector molecules for deoR-like regulators are generally phosphorylated intermediates of the relevant metabolic pathway. The DNA-binding deoR-type HTH domain occurs usually in the N-terminal part. The C-terminal part can contain an effector-binding domain and/or an oligomerisation domain. DeoR occurs as an octamer, whilst glpR and agaR are tetramers. Several operators may be bound simultaneously, which could facilitate DNA looping
[1, 3].
References
1.Opine catabolism and conjugal transfer of the nopaline Ti plasmid pTiC58 are coordinately regulated by a single repressor. Beck von Bodman S, Hayman GT, Farrand SK. Proc. Natl. Acad. Sci. U.S.A. 89, 643-7, (1992). View articlePMID: 1731335
2.Purification and characterization of the DeoR repressor of Bacillus subtilis. Zeng X, Saxild HH, Switzer RL. J. Bacteriol. 182, 1916-22, (2000). View articlePMID: 10714997
3.Application of AgaR repressor and dominant repressor variants for verification of a gene cluster involved in N-acetylgalactosamine metabolism in Escherichia coli K-12. Ray WK, Larson TJ. Mol. Microbiol. 51, 813-26, (2004). View articlePMID: 14731281
GO terms
biological process
molecular function
cellular component
- None
Cross References
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