D
IPR001093

IMP dehydrogenase/GMP reductase

InterPro entry
Short nameIMP_DH_GMPRt
Overlapping
homologous
superfamilies
 

Description

Synonym(s): Inosine-5'-monophosphate dehydrogenase, Inosinic acid dehydrogenase; Synonym(s): Guanosine 5'-monophosphate oxidoreductase

This entry contains two related enzymes: IMP dehydrogenase and GMP reductase. These enzymes adopt a TIM barrel structure.

IMP dehydrogenase (
1.1.1.205
) (IMPDH) catalyses the rate-limiting reaction ofde novoGTP biosynthesis, the NAD-dependent reduction of IMP into XMP
[3]
. Inosine 5-phosphate + NAD++ H2O = xanthosine 5-phosphate + NADH IMP dehydrogenase is associated with cell proliferation and is a possible target for cancer chemotherapy. Mammalian and bacterial IMPDHs are tetramers of identical chains. There are two IMP dehydrogenase isozymes in humans
[1]
. IMP dehydrogenase nearly always contains a long insertion that has two CBS domains within it.

GMP reductase (
1.7.1.7
) catalyses the irreversible and NADPH-dependent reductive deamination of GMP into IMP
[2]
. NADPH + guanosine 5-phosphate = NADP++ inosine 5-phosphate + NH3 It converts nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and maintains intracellular balance of A and G nucleotides.

References

1.Two distinct cDNAs for human IMP dehydrogenase. Natsumeda Y, Ohno S, Kawasaki H, Konno Y, Weber G, Suzuki K. J. Biol. Chem. 265, 5292-5, (1990). View articlePMID: 1969416

2.Nucleotide sequence of the gene encoding the GMP reductase of Escherichia coli K12. Andrews SC, Guest JR. Biochem. J. 255, 35-43, (1988). View articlePMID: 2904262

3.Cloning and sequence analysis of the human and Chinese hamster inosine-5'-monophosphate dehydrogenase cDNAs. Collart FR, Huberman E. J. Biol. Chem. 263, 15769-72, (1988). View articlePMID: 2902093

GO terms

biological process

  • None

cellular component

  • None

Cross References

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