F
IPR001103

Androgen receptor

InterPro entry
Short nameAndrgn_rcpt

Description

Steroid or nuclear hormone receptors (NRs) constitute an important super-family of transcription regulators that are involved in diverse physiological functions, including control of embryonic development, cell differentiation and homeostasis. Members include the steroid hormone receptors and receptors for thyroid hormone, retinoids and 1,25-dihydroxy-vitamin D3. The proteins function as dimeric molecules in the nucleus to regulate the transcription of target genes in a ligand-responsive manner
[2, 1]
.

References

1.Human androgen receptor expressed in HeLa cells activates transcription in vitro. De Vos P, Schmitt J, Verhoeven G, Stunnenberg HG. Nucleic Acids Res. 22, 1161-6, (1994). View articlePMID: 8165128

2.Vitamin D receptor contains multiple dimerization interfaces that are functionally different. Nishikawa J, Kitaura M, Imagawa M, Nishihara T. Nucleic Acids Res. 23, 606-11, (1995). View articlePMID: 7899080

Further reading

3. Molecular biology of the androgen receptor. Gelmann EP. J. Clin. Oncol. 20, 3001-15, (2002). View articlePMID: 12089231

4. Androgen receptor gene mutations identified by SSCP in fourteen subjects with androgen insensitivity syndrome. Batch JA, Williams DM, Davies HR, Brown BD, Evans BA, Hughes IA, Patterson MN. Hum. Mol. Genet. 1, 497-503, (1992). View articlePMID: 1307250

5. A single amino acid substitution (Met786----Val) in the steroid-binding domain of human androgen receptor leads to complete androgen insensitivity syndrome. Nakao R, Haji M, Yanase T, Ogo A, Takayanagi R, Katsube T, Fukumaki Y, Nawata H. J. Clin. Endocrinol. Metab. 74, 1152-7, (1992). View articlePMID: 1569163

GO terms

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