D
IPR001122

Capsid protein C, flavivirus

InterPro entry
Short nameFlavi_capsidC
Overlapping
homologous
superfamilies
 

Description

Flaviruses are small, enveloped RNA viruses that use arthropods such as mosquitoes for transmission to their vertebrate hosts, and include Yellow fever virus, West Nile virus, Tick-borne encephalitis virus, Japanese encephalitis virus, and Dengue virus 2
[1]
. Flaviviruses consist of three structural proteins: the core nucleocapsid protein C, and the envelope glycoproteins M (
IPR000069
) and E. The virion of these viruses is a nucleocapsid covered by a lipoprotein envelope, where the nucleocapsid is a complex of capsid protein C and mRNA. The capsid protein C is a dimeric α-helical protein, and its interaction with RNA is critical for the production of viable virus particles
[2]
.

References

1.Transmission cycles, host range, evolution and emergence of arboviral disease. Weaver SC, Barrett AD. Nat. Rev. Microbiol. 2, 789-801, (2004). View articlePMID: 15378043

2.Flavivirus capsid is a dimeric alpha-helical protein. Jones CT, Ma L, Burgner JW, Groesch TD, Post CB, Kuhn RJ. J. Virol. 77, 7143-9, (2003). View articlePMID: 12768036

GO terms

biological process

  • None

cellular component

Cross References

Contributing Member Database Entry
This website requires cookies, and the limited processing of your personal data in order to function. By using the site you are agreeing to this as outlined in our Privacy Notice and Terms of Use.