IPR001122
Capsid protein C, flavivirus
InterPro entry
Short name | Flavi_capsidC |
Overlapping homologous superfamilies |
Description
Flaviruses are small, enveloped RNA viruses that use arthropods such as mosquitoes for transmission to their vertebrate hosts, and include Yellow fever virus, West Nile virus, Tick-borne encephalitis virus, Japanese encephalitis virus, and Dengue virus 2
[1]. Flaviviruses consist of three structural proteins: the core nucleocapsid protein C, and the envelope glycoproteins M (
IPR000069) and E. The virion of these viruses is a nucleocapsid covered by a lipoprotein envelope, where the nucleocapsid is a complex of capsid protein C and mRNA. The capsid protein C is a dimeric α-helical protein, and its interaction with RNA is critical for the production of viable virus particles
[2].
References
1.Transmission cycles, host range, evolution and emergence of arboviral disease. Weaver SC, Barrett AD. Nat. Rev. Microbiol. 2, 789-801, (2004). View articlePMID: 15378043
2.Flavivirus capsid is a dimeric alpha-helical protein. Jones CT, Ma L, Burgner JW, Groesch TD, Post CB, Kuhn RJ. J. Virol. 77, 7143-9, (2003). View articlePMID: 12768036
GO terms
biological process
- None
molecular function
cellular component
Cross References
Contributing Member Database Entry
- Pfam:PF01003
Representative structure
5ygh: Crystal Structure of the Capsid Protein from Zika Virus