D
IPR001124

Lipid-binding serum glycoprotein, C-terminal

InterPro entry
Short nameLipid-bd_serum_glycop_C
Overlapping
homologous
superfamilies
 

Description

This entry represents the C-terminal domain found in several lipid-binding serum glycoproteins. The N- and C-terminal domains share a similar two-layer α/β structure, but they show little sequence identity. Proteins containing this C-terminal domain include:


 * Bactericidal permeability-increasing protein (BPI)
 * Lipopolysaccharide-binding protein (LBP)
 * Cholesteryl ester transfer protein (CETP)
 * Phospholipid transfer protein (PLTP)
 * Palate, lung and nasal epithelium carcinoma-associated protein (PLUNC)


Bactericidal permeability-increasing protein (BPI) is a potent antimicrobial protein of 456 residues that binds to and neutralises lipopolysaccharides from the outer membrane of Gram-negative bacteria
[1]
. BPI contains two domains that adopt the same structural fold, even though they have little sequence similarity
[2]
.

References

1.Crystal structure of human BPI and two bound phospholipids at 2.4 angstrom resolution. Beamer LJ, Carroll SF, Eisenberg D. Science 276, 1861-4, (1997). View articlePMID: 9188532

2.The 1.7 A crystal structure of BPI: a study of how two dissimilar amino acid sequences can adopt the same fold. Kleiger G, Beamer LJ, Grothe R, Mallick P, Eisenberg D. J. Mol. Biol. 299, 1019-34, (2000). View articlePMID: 10843855

Further reading

3. Bactericidal/permeability-increasing protein (BPI) and lipopolysaccharide-binding protein (LBP): structure, function and regulation in host defence against Gram-negative bacteria. Weiss J. Biochem. Soc. Trans. 31, 785-90, (2003). View articlePMID: 12887306

4. Crystal structure of CETP: new hopes for raising HDL to decrease risk of cardiovascular disease? Hamilton JA, Deckelbaum RJ. Nat. Struct. Mol. Biol. 14, 95-7, (2007). View articlePMID: 17277799

5. Structural and functional determinants of human plasma phospholipid transfer protein activity as revealed by site-directed mutagenesis of charged amino acids. Ponsin G, Qu SJ, Fan HZ, Pownall HJ. Biochemistry 42, 4444-51, (2003). View articlePMID: 12693940

6. PLUNC is a secreted product of neutrophil granules. Bartlett JA, Hicks BJ, Schlomann JM, Ramachandran S, Nauseef WM, McCray PB Jr. J. Leukoc. Biol. 83, 1201-6, (2008). View articlePMID: 18245229

7. Intracellular co-localization of SPLUNC1 protein with nanobacteria in nasopharyngeal carcinoma epithelia HNE1 cells depended on the bactericidal permeability increasing protein domain. Zhou HD, Li GY, Yang YX, Li XL, Sheng SR, Zhang WL, Zhao J. Mol. Immunol. 43, 1864-71, (2006). View articlePMID: 16364440

GO terms

biological process

  • None

molecular function

cellular component

  • None

Cross References

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