F
IPR001171

Sterol biosynthesis ERG24/DHCR-like

InterPro entry
Short nameERG24_DHCR-like

Description

This entry represents a group of enzymes involved in the steroid biosynthetic pathway, including 7-dehydrocholesterol reductase and Delta(14)-sterol reductase LBR (lamin B receptor) from animals
[5, 3, 4]
, Delta(14)-sterol reductase from fungi and plants
[7, 6, 2]
and Delta(24(24(1)))-sterol reductase from yeast
[1]
. These proteins act by reducing double bonds in precursors of ergosterol, are highly hydrophobic and seem to contain seven or eight transmembrane regions.

References

1.The identification of a gene family in the Saccharomyces cerevisiae ergosterol biosynthesis pathway. Lai MH, Bard M, Pierson CA, Alexander JF, Goebl M, Carter GT, Kirsch DR. Gene 140, 41-9, (1994). View articlePMID: 8125337

2.A sterol C-14 reductase encoded by FgERG24B is responsible for the intrinsic resistance of Fusarium graminearum to amine fungicides. Liu X, Fu J, Yun Y, Yin Y, Ma Z. Microbiology (Reading) 157, 1665-1675, (2011). PMID: 21436218

3.The Lamin B receptor is essential for cholesterol synthesis and perturbed by disease-causing mutations. Tsai PL, Zhao C, Turner E, Schlieker C. Elife 5, (2016). PMID: 27336722

4.The lamin B receptor of Drosophila melanogaster. Wagner N, Weber D, Seitz S, Krohne G. J Cell Sci 117, 2015-28, (2004). PMID: 15054108

5.The terminal enzymes of cholesterol synthesis, DHCR24 and DHCR7, interact physically and functionally. Luu W, Hart-Smith G, Sharpe LJ, Brown AJ. J Lipid Res 56, 888-97, (2015). PMID: 25637936

6.A critical role of sterols in embryonic patterning and meristem programming revealed by the fackel mutants of Arabidopsis thaliana. Jang JC, Fujioka S, Tasaka M, Seto H, Takatsuto S, Ishii A, Aida M, Yoshida S, Sheen J. Genes Dev 14, 1485-97, (2000). PMID: 10859167

7.Candida albicans sterol C-14 reductase, encoded by the ERG24 gene, as a potential antifungal target site. Jia N, Arthington-Skaggs B, Lee W, Pierson CA, Lees ND, Eckstein J, Barbuch R, Bard M. Antimicrob Agents Chemother 46, 947-57, (2002). PMID: 11897574

GO terms

Cross References

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