Citron homology (CNH) domain
Short name | CNH_dom |
Description
* Citron and Citron kinase. These two proteins interact with the GTP-bound forms of the small GTPases Rho and Rac but not with Cdc42.
* Myotonic dystrophy kinase-related Cdc42-binding kinase (MRCKalpha). This serine/threonine kinase interacts with the GTP-bound form of the small GTPase Cdc42 and to a lesser extent with that of Rac.
* NCK Interacting Kinase (NIK), a serine/threonine protein kinase.
* ROM-1 and ROM-2, from yeast. These proteins are GDP/GTP exchange proteins (GEPs) for the small GTP binding protein Rho1.
References
1.The myotonic dystrophy kinase-related Cdc42-binding kinase is involved in the regulation of neurite outgrowth in PC12 cells. Chen XQ, Tan I, Leung T, Lim L. J. Biol. Chem. 274, 19901-5, (1999). View articlePMID: 10391936
2.NIK is a new Ste20-related kinase that binds NCK and MEKK1 and activates the SAPK/JNK cascade via a conserved regulatory domain. Su YC, Han J, Xu S, Cobb M, Skolnik EY. EMBO J. 16, 1279-90, (1997). View articlePMID: 9135144
3.Human Vam6p promotes lysosome clustering and fusion in vivo. Caplan S, Hartnell LM, Aguilar RC, Naslavsky N, Bonifacino JS. J. Cell Biol. 154, 109-22, (2001). View articlePMID: 11448994
4.Septum formation is regulated by the RHO4-specific exchange factors BUD3 and RGF3 and by the landmark protein BUD4 in Neurospora crassa. Justa-Schuch D, Heilig Y, Richthammer C, Seiler S. Mol Microbiol 76, 220-35, (2010). PMID: 20199606
Cross References
ENZYME