D
IPR001190

SRCR domain

InterPro entry
Short nameSRCR
Overlapping
homologous
superfamilies
 

Description

The scavenger receptor cysteine-rich (SRCR) domain is an ancient and highly conserved domain of about 110 residues which is found in diverse secreted and cell-surface proteins, like the type I scavenger receptor, the speract receptor, CD5/Ly-1, CD6, or complement factor I
[2]
. Tandem repeats of SRCR domains are common in the membrane bound proteins. Most SRCR domains have six to eight cysteines that participate in intradomain disulfide bonds. SRCR domains have been subdivided into two groups, A and B, primarily on the differences in the spacing pattern between the cysteine residues
[1, 3]
.

Although the biochemical functions of SRCR domains have not been established with certainty, they are likely to mediate protein-protein interactions and ligand binding
[1, 3]
.

Determination of the crystal structure of the SRCR domain of M2BP reveals that the M2NP SRCR adopts a compact fold of approximate dimensions 22 x 26 x 30 Angstrom, organised around a curved six-stranded β-sheet cradling an alpha- helix
[3]
.

References

1.The SRCR superfamily: a family reminiscent of the Ig superfamily. Resnick D, Pearson A, Krieger M. Trends Biochem. Sci. 19, 5-8, (1994). View articlePMID: 8140623

2.An ancient, highly conserved family of cysteine-rich protein domains revealed by cloning type I and type II murine macrophage scavenger receptors. Freeman M, Ashkenas J, Rees DJ, Kingsley DM, Copeland NG, Jenkins NA, Krieger M. Proc. Natl. Acad. Sci. U.S.A. 87, 8810-4, (1990). View articlePMID: 1978939

3.Crystal structure of a scavenger receptor cysteine-rich domain sheds light on an ancient superfamily. Hohenester E, Sasaki T, Timpl R. Nat. Struct. Biol. 6, 228-32, (1999). View articlePMID: 10074941

Further reading

4. Spinesin/TMPRSS5, a novel transmembrane serine protease, cloned from human spinal cord. Yamaguchi N, Okui A, Yamada T, Nakazato H, Mitsui S. J Biol Chem 277, 6806-12, (2002). View articlePMID: 11741986

GO terms

biological process

  • None

molecular function

  • None

cellular component

Cross References

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