F
IPR001248

Purine-cytosine permease

InterPro entry
Short namePur-cyt_permease
family relationships

Description

This entry represents the purine-cytosine permease family, whose members include allantoin permease Dal4
[1]
, nicotinamide riboside transporter 1 (Nrt1)
[2]
, purine-cytosine permease Fcy2/21/22
[3]
, thiamine transporter Thi7/Thi72
[4]
, uracil permease Fur4
[6]
, uridine permease Fui1
[8]
and vitamin B6 transporter Tpn1
[5]
from budding yeasts. This entry also includes cytosine permeases codB from E. coli
[7]
and purine-uracil permease AtNCS1 from Arabidopsis
[9]
.

References

1.The allantoin and uracil permease gene sequences of Saccharomyces cerevisiae are nearly identical. Yoo HS, Cunningham TS, Cooper TG. Yeast 8, 997-1006, (1992). View articlePMID: 1293888

2.Saccharomyces cerevisiae YOR071C encodes the high affinity nicotinamide riboside transporter Nrt1. Belenky PA, Moga TG, Brenner C. J. Biol. Chem. 283, 8075-9, (2008). View articlePMID: 18258590

3.Functional analysis of mutated purine-cytosine permease from Saccharomyces cerevisiae. A possible role of the hydrophilic segment 371-377 in the active carrier conformation. Ferreira T, Brethes D, Pinson B, Napias C, Chevallier J. J. Biol. Chem. 272, 9697-702, (1997). View articlePMID: 9092500

4.Identification and characterization of the thiamine transporter gene of Saccharomyces cerevisiae. Singleton CK. Gene 199, 111-21, (1997). View articlePMID: 9358046

5.Tpn1p, the plasma membrane vitamin B6 transporter of Saccharomyces cerevisiae. Stolz J, Vielreicher M. J. Biol. Chem. 278, 18990-6, (2003). View articlePMID: 12649274

6.Growth inhibition of Saccharomyces cerevisiae by the immunosuppressant leflunomide is due to the inhibition of uracil uptake via Fur4p. Fujimura H. Mol. Gen. Genet. 260, 102-7, (1998). View articlePMID: 9829833

7.Characterization of the Escherichia coli codBA operon encoding cytosine permease and cytosine deaminase. Danielsen S, Kilstrup M, Barilla K, Jochimsen B, Neuhard J. Mol. Microbiol. 6, 1335-44, (1992). View articlePMID: 1640834

8.Characterization of the transport mechanism and permeant binding profile of the uridine permease Fui1p of Saccharomyces cerevisiae. Zhang J, Smith KM, Tackaberry T, Sun X, Carpenter P, Slugoski MD, Robins MJ, Nielsen LP, Nowak I, Baldwin SA, Young JD, Cass CE. J. Biol. Chem. 281, 28210-21, (2006). View articlePMID: 16854981

9.Structure-function relationship of a plant NCS1 member--homology modeling and mutagenesis identified residues critical for substrate specificity of PLUTO, a nucleobase transporter from Arabidopsis. Witz S, Panwar P, Schober M, Deppe J, Pasha FA, Lemieux MJ, Mohlmann T. PLoS ONE 9, e91343, (2014). View articlePMID: 24621654

GO terms

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