D
IPR001264

Glycosyl transferase, family 51

InterPro entry
Short nameGlyco_trans_51
Overlapping
homologous
superfamilies
 

Description

The biosynthesis of disaccharides, oligosaccharides and polysaccharides involves the action of hundreds of different glycosyltransferases. These enzymes catalyse the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. A classification of glycosyltransferases using nucleotide diphospho-sugar, nucleotide monophospho-sugar and sugar phosphates (
2.4.1.-
) and related proteins into distinct sequence based families has been described
[1]
. This classification is available on the CAZy (CArbohydrate-Active EnZymes) web site. The same three-dimensional fold is expected to occur within each of the families. Because 3-D structures are better conserved than sequences, several of the families defined on the basis of sequence similarities may have similar 3-D structures and therefore form 'clans'.

Glycosyltransferase family 51
GT51
comprises enzymes with only one known activity; murein polymerases (
2.4
). These enzymes utilise MurNAc-GlcNAc-P-P-lipid II as the sugar donor.

References

1.A classification of nucleotide-diphospho-sugar glycosyltransferases based on amino acid sequence similarities. Campbell JA, Davies GJ, Bulone V, Henrissat B. Biochem. J. 326 ( Pt 3), 929-39, (1997). View articlePMID: 9334165

Further reading

2. Topographical and functional investigation of Escherichia coli penicillin-binding protein 1b by alanine stretch scanning mutagenesis. Lefevre F, Remy MH, Masson JM. J. Bacteriol. 179, 4761-7, (1997). View articlePMID: 9244263

3. Monofunctional biosynthetic peptidoglycan transglycosylases. Spratt BG, Zhou J, Taylor M, Merrick MJ. Mol. Microbiol. 19, 639-40, (1996). View articlePMID: 8830253

Cross References

Contributing Member Database Entry
This website requires cookies, and the limited processing of your personal data in order to function. By using the site you are agreeing to this as outlined in our Privacy Notice and Terms of Use.