IPR001264
Glycosyl transferase, family 51
InterPro entry
Short name | Glyco_trans_51 |
Overlapping homologous superfamilies |
Description
The biosynthesis of disaccharides, oligosaccharides and polysaccharides involves the action of hundreds of different glycosyltransferases. These enzymes catalyse the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. A classification of glycosyltransferases using nucleotide diphospho-sugar, nucleotide monophospho-sugar and sugar phosphates (
2.4.1.-) and related proteins into distinct sequence based families has been described
[1]. This classification is available on the CAZy (CArbohydrate-Active EnZymes) web site. The same three-dimensional fold is expected to occur within each of the families. Because 3-D structures are better conserved than sequences, several of the families defined on the basis of sequence similarities may have similar 3-D structures and therefore form 'clans'.
References
1.A classification of nucleotide-diphospho-sugar glycosyltransferases based on amino acid sequence similarities. Campbell JA, Davies GJ, Bulone V, Henrissat B. Biochem. J. 326 ( Pt 3), 929-39, (1997). View articlePMID: 9334165
Further reading
2. Topographical and functional investigation of Escherichia coli penicillin-binding protein 1b by alanine stretch scanning mutagenesis. Lefevre F, Remy MH, Masson JM. J. Bacteriol. 179, 4761-7, (1997). View articlePMID: 9244263
3. Monofunctional biosynthetic peptidoglycan transglycosylases. Spratt BG, Zhou J, Taylor M, Merrick MJ. Mol. Microbiol. 19, 639-40, (1996). View articlePMID: 8830253
Cross References
Contributing Member Database Entry
- Pfam:PF00912