Pseudouridine synthase I, TruA
Short name | PsdUridine_synth_TruA |
Overlapping homologous superfamilies | |
family relationships |
Description
* Pseudouridine synthase I, TruA.
* Pseudouridine synthase II, TruB, which contains and additional C-terminal PUA domain.
* Pseudouridine synthase RsuA. RluB, RluE and RluF are also part of this family.
* Pseudouridine synthase RluA. TruC, RluC and RluD belong to this family.
* Pseudouridine synthase TruD, which has a natural circular permutation in the catalytic domain, as well as an insertion of a family-specific α+β subdomain.
References
1.Transfer RNA-pseudouridine synthetase Pus1 of Saccharomyces cerevisiae contains one atom of zinc essential for its native conformation and tRNA recognition. Arluison V, Hountondji C, Robert B, Grosjean H. Biochemistry 37, 7268-76, (1998). View articlePMID: 9585540
2.The structural basis for tRNA recognition and pseudouridine formation by pseudouridine synthase I. Foster PG, Huang L, Santi DV, Stroud RM. Nat. Struct. Biol. 7, 23-7, (2000). View articlePMID: 10625422
3.How U38, 39, and 40 of many tRNAs become the targets for pseudouridylation by TruA. Hur S, Stroud RM. Mol. Cell 26, 189-203, (2007). View articlePMID: 17466622
4.Role of cysteine residues in pseudouridine synthases of different families. Ramamurthy V, Swann SL, Spedaliere CJ, Mueller EG. Biochemistry 38, 13106-11, (1999). View articlePMID: 10529181
5.Transcriptome-wide mapping reveals widespread dynamic-regulated pseudouridylation of ncRNA and mRNA. Schwartz S, Bernstein DA, Mumbach MR, Jovanovic M, Herbst RH, Leon-Ricardo BX, Engreitz JM, Guttman M, Satija R, Lander ES, Fink G, Regev A. Cell 159, 148-162, (2014). PMID: 25219674
6.Pseudouridine synthetase Pus1 of Saccharomyces cerevisiae: kinetic characterisation, tRNA structural requirement and real-time analysis of its complex with tRNA. Arluison V, Buckle M, Grosjean H. J Mol Biol 289, 491-502, (1999). PMID: 10356324
7.mRNA structure determines modification by pseudouridine synthase 1. Carlile TM, Martinez NM, Schaening C, Su A, Bell TA, Zinshteyn B, Gilbert WV. Nat Chem Biol 15, 966-974, (2019). PMID: 31477916
8.The yeast tRNA:pseudouridine synthase Pus1p displays a multisite substrate specificity. Motorin Y, Keith G, Simon C, Foiret D, Simos G, Hurt E, Grosjean H. RNA 4, 856-69, (1998). View articlePMID: 9671058
9.Enzymatic characterization and mutational studies of TruD--the fifth family of pseudouridine synthases. Chan CM, Huang RH. Arch. Biochem. Biophys. 489, 15-9, (2009). View articlePMID: 19664587
GO terms
biological process
molecular function
cellular component
- None
Cross References
Contributing Member Database Entries
- CDD:cd02570
- HAMAP:MF_00171
- PIRSF:PIRSF001430
- NCBIfam:TIGR00071
- PANTHER:PTHR11142