F
IPR001422

Neuromodulin (GAP-43)

InterPro entry
Short nameNeuromodulin

Description

Neuromodulin (also known as growth-associated protein 43 or GAP-43) is a component of the motile growth cones. It is membrane protein whose expression is widely correlated with successful axon elongation
[1]
. It is a crucial component of an effective regeneration response in the nervous system
[2]
. Although its function is uncertain, the N-terminal region is well conserved and contains both a calmodulin binding domain, and sites for acylation, membrane attachment and protein kinase C phosphorylation. Structure predictions suggest that the C-terminal region may exist as an extended, negatively-charged rod with some similarity to the side arms of neurofilaments, indicating that the biological role of neuromodulin may depend on its ability to form a dynamic membrane-cytoplasm-calmodulin complex
[2]
.

References

1.Human GAP-43: its deduced amino acid sequence and chromosomal localization in mouse and human. Kosik KS, Orecchio LD, Bruns GA, Benowitz LI, MacDonald GP, Cox DR, Neve RL. Neuron 1, 127-32, (1988). View articlePMID: 3272162

2.Selective conservation of GAP-43 structure in vertebrate evolution. LaBate ME, Skene JH. Neuron 3, 299-310, (1989). View articlePMID: 2641999

GO terms

molecular function

  • None

cellular component

  • None

Cross References

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