C3a anaphylatoxin chemotactic receptor
Short name | Anaphtx_C3AR1 |
family relationships |
Description
References
1.cDNA cloning of a novel G protein-coupled receptor with a large extracellular loop structure. Roglic A, Prossnitz ER, Cavanagh SL, Pan Z, Zou A, Ye RD. Biochim. Biophys. Acta 1305, 39-43, (1996). View articlePMID: 8605247
2.The chemotactic receptor for human C5a anaphylatoxin. Gerard NP, Gerard C. Nature 349, 614-7, (1991). View articlePMID: 1847994
3.Identification of four novel human G protein-coupled receptors expressed in the brain. Lee DK, George SR, Cheng R, Nguyen T, Liu Y, Brown M, Lynch KR, O'Dowd BF. Brain Res. Mol. Brain Res. 86, 13-22, (2001). View articlePMID: 11165367
4.C5A anaphylatoxin and its seven transmembrane-segment receptor. Gerard C, Gerard NP. Annu. Rev. Immunol. 12, 775-808, (1994). View articlePMID: 8011297
5.C5L2 is critical for the biological activities of the anaphylatoxins C5a and C3a. Chen NJ, Mirtsos C, Suh D, Lu YC, Lin WJ, McKerlie C, Lee T, Baribault H, Tian H, Yeh WC. Nature 446, 203-7, (2007). View articlePMID: 17322907
6.Phylogenetic analysis of 277 human G-protein-coupled receptors as a tool for the prediction of orphan receptor ligands. Joost P, Methner A. Genome Biol. 3, RESEARCH0063, (2002). PMID: 12429062
7.C5L2 is a functional receptor for acylation-stimulating protein. Kalant D, MacLaren R, Cui W, Samanta R, Monk PN, Laporte SA, Cianflone K. J. Biol. Chem. 280, 23936-44, (2005). View articlePMID: 15833747
8.Identification of a selective nonpeptide antagonist of the anaphylatoxin C3a receptor that demonstrates antiinflammatory activity in animal models. Ames RS, Lee D, Foley JJ, Jurewicz AJ, Tornetta MA, Bautsch W, Settmacher B, Klos A, Erhard KF, Cousins RD, Sulpizio AC, Hieble JP, McCafferty G, Ward KW, Adams JL, Bondinell WE, Underwood DC, Osborn RR, Badger AM, Sarau HM. J. Immunol. 166, 6341-8, (2001). PMID: 11342658
9.The C3a receptor antagonist SB 290157 has agonist activity. Mathieu MC, Sawyer N, Greig GM, Hamel M, Kargman S, Ducharme Y, Lau CK, Friesen RW, O'Neill GP, Gervais FG, Therien AG. Immunol. Lett. 100, 139-45, (2005). View articlePMID: 16154494
10.Molecular cloning and characterization of the human anaphylatoxin C3a receptor. Ames RS, Li Y, Sarau HM, Nuthulaganti P, Foley JJ, Ellis C, Zeng Z, Su K, Jurewicz AJ, Hertzberg RP, Bergsma DJ, Kumar C. J. Biol. Chem. 271, 20231-4, (1996). View articlePMID: 8702752
11.C3a and C5a stimulate chemotaxis of human mast cells. Hartmann K, Henz BM, Kruger-Krasagakes S, Kohl J, Burger R, Guhl S, Haase I, Lippert U, Zuberbier T. Blood 89, 2863-70, (1997). PMID: 9108406
12.De novo peptide design with C3a receptor agonist and antagonist activities: theoretical predictions and experimental validation. Bellows-Peterson ML, Fung HK, Floudas CA, Kieslich CA, Zhang L, Morikis D, Wareham KJ, Monk PN, Hawksworth OA, Woodruff TM. J. Med. Chem. 55, 4159-68, (2012). View articlePMID: 22500977
13.Degranulation from human eosinophils stimulated with C3a and C5a. Takafuji S, Tadokoro K, Ito K, Dahinden CA. Int. Arch. Allergy Immunol. 104 Suppl 1, 27-9, (1994). PMID: 8156000
14.C5a mutants are potent antagonists of the C5a receptor (CD88) and of C5L2: position 69 is the locus that determines agonism or antagonism. Otto M, Hawlisch H, Monk PN, Muller M, Klos A, Karp CL, Kohl J. J. Biol. Chem. 279, 142-51, (2004). View articlePMID: 14570896
15.Function, structure and therapeutic potential of complement C5a receptors. Monk PN, Scola AM, Madala P, Fairlie DP. Br. J. Pharmacol. 152, 429-48, (2007). View articlePMID: 17603557
16.Interaction between the coagulation and complement system. Amara U, Rittirsch D, Flierl M, Bruckner U, Klos A, Gebhard F, Lambris JD, Huber-Lang M. Adv. Exp. Med. Biol. 632, 71-9, (2008). PMID: 19025115
17.The role of anaphylatoxins C3a and C5a in regulating innate and adaptive immune responses. Peng Q, Li K, Sacks SH, Zhou W. Inflamm Allergy Drug Targets 8, 236-46, (2009). View articlePMID: 19601884
18.Complement fragment C3a controls mutual cell attraction during collective cell migration. Carmona-Fontaine C, Theveneau E, Tzekou A, Tada M, Woods M, Page KM, Parsons M, Lambris JD, Mayor R. Dev. Cell 21, 1026-37, (2011). View articlePMID: 22118769
19.The role of the anaphylatoxins in health and disease. Klos A, Tenner AJ, Johswich KO, Ager RR, Reis ES, Kohl J. Mol. Immunol. 46, 2753-66, (2009). View articlePMID: 19477527
20.C3a and C5a are chemotactic factors for human mesenchymal stem cells, which cause prolonged ERK1/2 phosphorylation. Schraufstatter IU, Discipio RG, Zhao M, Khaldoyanidi SK. J. Immunol. 182, 3827-36, (2009). View articlePMID: 19265162
21.Human anaphylatoxin C4a is a potent agonist of the guinea pig but not the human C3a receptor. Lienenklaus S, Ames RS, Tornetta MA, Sarau HM, Foley JJ, Crass T, Sohns B, Raffetseder U, Grove M, Holzer A, Klos A, Kohl J, Bautsch W. J. Immunol. 161, 2089-93, (1998). PMID: 9725198
22.Th17 cytokines are critical for respiratory syncytial virus-associated airway hyperreponsiveness through regulation by complement C3a and tachykinins. Bera MM, Lu B, Martin TR, Cui S, Rhein LM, Gerard C, Gerard NP. J. Immunol. 187, 4245-55, (2011). View articlePMID: 21918196
23.A novel role of complement in retinal degeneration. Yu M, Zou W, Peachey NS, McIntyre TM, Liu J. Invest. Ophthalmol. Vis. Sci. 53, 7684-92, (2012). View articlePMID: 23074214
24.Characterization of receptors to the anaphylatoxins on isolated cells. Fukuoka Y, Nielsen LP, Hugli TE. Dermatologica 179 Suppl 1, 35-40, (1989). PMID: 2528484
25.Role of C3a receptors, C5a receptors, and complement protein C6 deficiency in collagen antibody-induced arthritis in mice. Banda NK, Hyatt S, Antonioli AH, White JT, Glogowska M, Takahashi K, Merkel TJ, Stahl GL, Mueller-Ortiz S, Wetsel R, Arend WP, Holers VM. J. Immunol. 188, 1469-78, (2012). View articlePMID: 22205026
26.Expression cloning of the human C3a anaphylatoxin receptor (C3aR) from differentiated U-937 cells. Crass T, Raffetseder U, Martin U, Grove M, Klos A, Kohl J, Bautsch W. Eur. J. Immunol. 26, 1944-50, (1996). View articlePMID: 8765043
GO terms
molecular function
cellular component
Contributing Member Database Entry
- PRINTS:PR01060