IPR001754
Orotidine 5'-phosphate decarboxylase domain
InterPro entry
Short name | OMPdeCOase_dom |
Overlapping homologous superfamilies | |
domain relationships |
Description
Orotidine 5'-phosphate decarboxylase (OMPdecase)
[1, 2] catalyses the last step in thede novobiosynthesis of pyrimidines, the decarboxylation of OMP into UMP. In higher eukaryotes OMPdecase is part, with orotate phosphoribosyltransferase, of a bifunctional enzyme, while the prokaryotic and fungal OMPdecases are monofunctional protein.
Some parts of the sequence of OMPdecase are well conserved across species. The best conserved region is located in the N-terminal half of OMPdecases and is centred around a lysine residue which is essential for the catalytic function of the enzyme.
References
1.Sequence analysis of the DdPYR5-6 gene coding for UMP synthase in Dictyostelium discoideum and comparison with orotate phosphoribosyl transferases and OMP decarboxylases. Jacquet M, Guilbaud R, Garreau H. Mol. Gen. Genet. 211, 441-5, (1988). View articlePMID: 2835631
2.The orotidine-5'-monophosphate decarboxylase gene of Myxococcus xanthus. Comparison to the OMP decarboxylase gene family. Kimsey HH, Kaiser D. J. Biol. Chem. 267, 819-24, (1992). View articlePMID: 1730672
GO terms
biological process
molecular function
cellular component
- None
Cross References
Representative structure
3ajx: Crystal Structure of 3-Hexulose-6-Phosphate Synthase