D
IPR001774

Delta/Serrate/lag-2 (DSL) protein

InterPro entry
Short nameDSL

Description

Ligands of the Delta/Serrate/lag-2 (DSL) family and their receptors, members of the lin-12/Notch family, mediate cell-cell interactions that specify cell fate in invertebrates and vertebrates. In Caenorhabditis elegans, two DSL genes, lag-2 and apx-1, influence different cell fate decisions during development
[1]
. Molecular interaction between Notch and Serrate, another EGF-homologous transmembrane protein containing a region of striking similarity to Delta, has been shown and the same two EGF repeats of Notch may also constitute a Serrate binding domain
[2, 3]
.

References

1.Interchangeability of Caenorhabditis elegans DSL proteins and intrinsic signalling activity of their extracellular domains in vivo. Fitzgerald K, Greenwald I. Development 121, 4275-82, (1995). View articlePMID: 8575327

2.Specific EGF repeats of Notch mediate interactions with Delta and Serrate: implications for Notch as a multifunctional receptor. Rebay I, Fleming RJ, Fehon RG, Cherbas L, Cherbas P, Artavanis-Tsakonas S. Cell 67, 687-99, (1991). View articlePMID: 1657403

3.Notch signaling. Artavanis-Tsakonas S, Matsuno K, Fortini ME. Science 268, 225-32, (1995). View articlePMID: 7716513

GO terms

molecular function

  • None

cellular component

Cross References

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