F
IPR001819

Chromogranin A/B

InterPro entry
Short nameChromogranin_AB
family relationships

Description

Chromogranins and secretogranins are acidic proteins present in the secretory granules of endocrine and neuro-endocrine cells
[1, 2]
. Granins may be precursors of biologically-active peptides, or they may be helper proteins in the packaging of peptide hormones and neuropeptides - their precise role is unclear.

Chromogranins A and B are characterised by an N-terminal motif that includes 2 cysteine residues involved in disulphide bond formation.

References

1.The granin (chromogranin/secretogranin) family. Huttner WB, Gerdes HH, Rosa P. Trends Biochem. Sci. 16, 27-30, (1991). View articlePMID: 2053134

2.Biochemistry of the chromogranin A protein family. Simon JP, Aunis D. Biochem. J. 262, 1-13, (1989). View articlePMID: 2684154

GO terms

biological process

  • None

molecular function

  • None

Cross References

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