Protease inhibitor I35 (TIMP)
Short name | TIMP |
Overlapping homologous superfamilies |
Description
+-----------------------------+ +--------------+ | | | | CxCxCxxxxxxxxxxxxxxxxxCxxxxxxxxxCxxxxxxxCxCxCxCxCxxxxxCxxCxxx | | | | | | | | | +-----------------|-----------------+ +-+ +-----+ +---------------------+ 'C': conserved cysteine involved in a disulphide bond.
References
1.Tissue inhibitor of metalloproteinase (TIMP-2). A new member of the metalloproteinase inhibitor family. Stetler-Stevenson WG, Krutzsch HC, Liotta LA. J. Biol. Chem. 264, 17374-8, (1989). View articlePMID: 2793861
2.Matrix metalloproteinases and their inhibitors in connective tissue remodeling. Woessner JF Jr. FASEB J. 5, 2145-54, (1991). View articlePMID: 1850705
3.A new inhibitor of metalloproteinases from chicken: ChIMP-3. A third member of the TIMP family. Pavloff N, Staskus PW, Kishnani NS, Hawkes SP. J. Biol. Chem. 267, 17321-6, (1992). View articlePMID: 1512267
4.Solution structure of the active domain of tissue inhibitor of metalloproteinases-2. A new member of the OB fold protein family. Williamson RA, Martorell G, Carr MD, Murphy G, Docherty AJ, Freedman RB, Feeney J. Biochemistry 33, 11745-59, (1994). View articlePMID: 7918391
5.Disulphide bond assignment in human tissue inhibitor of metalloproteinases (TIMP). Williamson RA, Marston FA, Angal S, Koklitis P, Panico M, Morris HR, Carne AF, Smith BJ, Harris TJ, Freedman RB. Biochem. J. 268, 267-74, (1990). View articlePMID: 2163605
6.Structural insight into the complex formation of latent matrix metalloproteinase 2 with tissue inhibitor of metalloproteinase 2. Morgunova E, Tuuttila A, Bergmann U, Tryggvason K. Proc. Natl. Acad. Sci. U.S.A. 99, 7414-9, (2002). View articlePMID: 12032297
7.Timp1 interacts with beta-1 integrin and CD63 along melanoma genesis and confers anoikis resistance by activating PI3-K signaling pathway independently of Akt phosphorylation. Toricelli M, Melo FH, Peres GB, Silva DC, Jasiulionis MG. Mol. Cancer 12, 22, (2013). PMID: 23522389
8.Matrix metalloproteinase-10 (MMP-10) interaction with tissue inhibitors of metalloproteinases TIMP-1 and TIMP-2: binding studies and crystal structure. Batra J, Robinson J, Soares AS, Fields AP, Radisky DC, Radisky ES. J. Biol. Chem. 287, 15935-46, (2012). View articlePMID: 22427646
GO terms
biological process
- None
molecular function
cellular component
- None
Cross References
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