F
IPR001874

Dehydroquinase, class II

InterPro entry
Short nameDHquinase_II
Overlapping
homologous
superfamilies
 

Description

3-dehydroquinate dehydratase (
4.2.1.10
), or dehydroquinase, catalyzes the conversion of 3-dehydroquinate into 3-dehydroshikimate. It is the third step in the shikimate pathway for the biosynthesis of aromatic amino acids from chorismate. Two classes of dehydroquinases exist, known as types I and II. Class-II enzymes are homododecameric enzymes of about 17kDa. They are found in some bacteria such as actinomycetales
[1, 2]
and some fungi where they act in a catabolic pathway that allows the use of quinic acid as a carbon source.

References

1.The Mycobacterium tuberculosis shikimate pathway genes: evolutionary relationship between biosynthetic and catabolic 3-dehydroquinases. Garbe T, Servos S, Hawkins A, Dimitriadis G, Young D, Dougan G, Charles I. Mol. Gen. Genet. 228, 385-92, (1991). View articlePMID: 1910148

2.Characterization of a 3-dehydroquinase gene from Actinobacillus pleuropneumoniae with homology to the eukaryotic genes qa-2 and QUTE. Lalonde G, O'Hanley PD, Stocker BA, Denich KT. Mol. Microbiol. 11, 273-80, (1994). View articlePMID: 8170389

GO terms

biological process

  • None

cellular component

  • None

Cross References

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