IPR001874
Dehydroquinase, class II
InterPro entry
Short name | DHquinase_II |
Overlapping homologous superfamilies |
Description
3-dehydroquinate dehydratase (
4.2.1.10), or dehydroquinase, catalyzes the conversion of 3-dehydroquinate into 3-dehydroshikimate. It is the third step in the shikimate pathway for the biosynthesis of aromatic amino acids from chorismate. Two classes of dehydroquinases exist, known as types I and II. Class-II enzymes are homododecameric enzymes of about 17kDa. They are found in some bacteria such as actinomycetales
[1, 2] and some fungi where they act in a catabolic pathway that allows the use of quinic acid as a carbon source.
References
1.The Mycobacterium tuberculosis shikimate pathway genes: evolutionary relationship between biosynthetic and catabolic 3-dehydroquinases. Garbe T, Servos S, Hawkins A, Dimitriadis G, Young D, Dougan G, Charles I. Mol. Gen. Genet. 228, 385-92, (1991). View articlePMID: 1910148
2.Characterization of a 3-dehydroquinase gene from Actinobacillus pleuropneumoniae with homology to the eukaryotic genes qa-2 and QUTE. Lalonde G, O'Hanley PD, Stocker BA, Denich KT. Mol. Microbiol. 11, 273-80, (1994). View articlePMID: 8170389
GO terms
biological process
- None
molecular function
cellular component
- None
Cross References
PROSITE Doc
ENZYME
Genome Properties
Representative structure
6hsa: The crystal structure of type II Dehydroquinase from Butyrivibrio crossotus DSM 2876