Ras guanine-nucleotide exchange factors catalytic domain
Short name | RASGEF_cat_dom |
Overlapping homologous superfamilies |
Description
* Cdc25 from yeast.
* Scd25 from yeast.
* Ste6 from fission yeast.
* Son of sevenless (gene sos) from Drosophila and mammals.
* p140-RAS GRF (cdc25Mm) from mammals. This protein possesses both a domain belonging to the CDC25 family and one belonging to the CDC24 family.
* Bud5 from yeast, that may interact with the ras-like protein RSR1/BUD1.
* Lte1 from yeast, whose target protein is not yet known.
* ralGDS from mammals, which interacts with the ras-like proteins ralA and ralB
References
1.The GTPase superfamily: conserved structure and molecular mechanism. Bourne HR, Sanders DA, McCormick F. Nature 349, 117-27, (1991). View articlePMID: 1898771
2.Coupling of Ras and Rac guanosine triphosphatases through the Ras exchanger Sos. Nimnual AS, Yatsula BA, Bar-Sagi D. Science 279, 560-3, (1998). View articlePMID: 9438849
3.Ras regulation: putting back the GTP. Downward J. Curr. Biol. 2, 329-31, (1992). View articlePMID: 15335949
4.Characterization of a guanine nucleotide dissociation stimulator for a ras-related GTPase. Albright CF, Giddings BW, Liu J, Vito M, Weinberg RA. EMBO J. 12, 339-47, (1993). View articlePMID: 8094051
5.Proteins regulating Ras and its relatives. Boguski MS, McCormick F. Nature 366, 643-54, (1993). View articlePMID: 8259209
6.Guanine nucleotide exchange factors: activators of the Ras superfamily of proteins. Quilliam LA, Khosravi-Far R, Huff SY, Der CJ. Bioessays 17, 395-404, (1995). View articlePMID: 7786285
GO terms
biological process
molecular function
cellular component
- None
Cross References
PROSITE Doc
ENZYME
Genome Properties