F
IPR002061

Scorpion long chain toxin/defensin

InterPro entry
Short nameScorpion_toxinL/defensin
Overlapping
homologous
superfamilies
 

Description

This family contains both neurotoxins and plant defensins. The mustard trypsin inhibitor, MTI-2, is a plant defensin. It is a potent inhibitor of trypsin with no activity towards chymotrypsin. MTI-2 is toxic for Lepidopteran insects, but has low activity against aphids
[3]
. The scorpion toxin (a neurotoxin) binds to sodium channels and inhibits the activation mechanisms of the channels, thereby blocking neuronal transmission
[2, 1]
.

References

1.Structural basis of α-scorpion toxin action on Na<sub>v</sub> channels. Clairfeuille T, Cloake A, Infield DT, Llongueras JP, Arthur CP, Li ZR, Jian Y, Martin-Eauclaire MF, Bougis PE, Ciferri C, Ahern CA, Bosmans F, Hackos DH, Rohou A, Payandeh J. Science 363, (2019). PMID: 30733386

2.Expression and purification of recombinant alpha-toxin AnCra1 from the scorpion Androctonus crassicauda and its functional characterization on mammalian sodium channels. Bayatzadeh MA, Zare Mirakabadi A, Babaei N, Doulah A, Doosti A. Mol Biol Rep 48, 6303-6312, (2021). PMID: 34379289

3.Selection by phage display of a variant mustard trypsin inhibitor toxic against aphids. Ceci LR, Volpicella M, Rahbe Y, Gallerani R, Beekwilder J, Jongsma MA. Plant J. 33, 557-66, (2003). View articlePMID: 12581313

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