F
IPR002161

Pyridoxal 5'-phosphate synthase subunit PdxT/SNO

InterPro entry
Short namePdxT/SNO
Overlapping
homologous
superfamilies
 

Description

This entry represents a family of pyridoxal 5'-phosphate synthase subunit, also known as the pdxT/SNO family. This family belongs to a superfamily containing a triad glutamine aminotransferase fold, characterised by a conserved Cys-His-Glu active site
[1]
. Two regions are highly conserved across all taxa, the PGGEST motif and the FHPE(LT) motif
[2]
. PdxT/SNO proteins are an α/β three-layer sandwich containing a seven- stranded twisted mixed parallel β-sheet flanked by a six α-helices on the N-terminal stretch of the sheet, four on one side and two on the other
[1]
. They are involved in vitamin B6 biosynthesis.

References

1.Three-dimensional structure of YaaE from Bacillus subtilis, a glutaminase implicated in pyridoxal-5'-phosphate biosynthesis. Bauer JA, Bennett EM, Begley TP, Ealick SE. J. Biol. Chem. 279, 2704-11, (2004). View articlePMID: 14585832

2.Isolation of PDX2, a second novel gene in the pyridoxine biosynthesis pathway of eukaryotes, archaebacteria, and a subset of eubacteria. Ehrenshaft M, Daub ME. J. Bacteriol. 183, 3383-90, (2001). View articlePMID: 11344146

Further reading

3. Characterization of the products of the genes SNO1 and SNZ1 involved in pyridoxine synthesis in Saccharomyces cerevisiae. Dong YX, Sueda S, Nikawa J, Kondo H. Eur. J. Biochem. 271, 745-52, (2004). View articlePMID: 14764090

4. Physical and enzymological interaction of Bacillus subtilis proteins required for de novo pyridoxal 5'-phosphate biosynthesis. Belitsky BR. J. Bacteriol. 186, 1191-6, (2004). View articlePMID: 14762015

GO terms

Cross References

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