S
IPR002173

Carbohydrate/purine kinase, PfkB, conserved site

InterPro entry
Short nameCarboh/pur_kinase_PfkB_CS

Description

It has been shown
[1, 2, 3]
that the following carbohydrate and purine kinases are evolutionary related and can be grouped into a single family, which is known
[1]
as the 'pfkB family':


 * Fructokinase (
2.7.1.4
) (gene scrK).
 * 6-phosphofructokinase isozyme 2 (
2.7.1.11
) (phosphofructokinase-2) (gene pfkB). pfkB is a minor phosphofructokinase isozyme in Escherichia coli and is not evolutionary related to the major isozyme (gene pfkA). Plant 6-phosphofructokinase also belong to this family.
 * Ribokinase (
2.7.1.15
) (gene rbsK).
 * Adenosine kinase (
2.7.1.20
) (gene ADK).
 * 2-dehydro-3-deoxygluconokinase (
2.7.1.45
) (gene: kdgK).
 * 1-phosphofructokinase (
2.7.1.56
) (fructose 1-phosphate kinase) (gene fruK).
 * Inosine-guanosine kinase (
2.7.1.73
) (gene gsk).
 * Tagatose-6-phosphate kinase (
2.7.1.144
) (phosphotagatokinase) (gene lacC).
 * E. coli hypothetical protein yeiC.
 * E. coli hypothetical protein yeiI.
 * E. coli hypothetical protein yhfQ.
 * E. coli hypothetical protein yihV.
 * Yeast hypothetical protein YJR105w.


All the above kinases are proteins of from 280 to 430 amino acid residues that share a few region of sequence similarity.

Note: some bacterial fructokinases belong to the ROK family (see
IPR000600
).

References

1.Nucleotide sequence of the Rhodobacter capsulatus fruK gene, which encodes fructose-1-phosphate kinase: evidence for a kinase superfamily including both phosphofructokinases of Escherichia coli. Wu LF, Reizer A, Reizer J, Cai B, Tomich JM, Saier MH Jr. J. Bacteriol. 173, 3117-27, (1991). View articlePMID: 1850730

2.Sequence similarities between the gene specifying 1-phosphofructokinase (fruK), genes specifying other kinases in Escherichia coli K12, and lacC of Staphylococcus aureus. Orchard LM, Kornberg HL. Proc. Biol. Sci. 242, 87-90, (1990). View articlePMID: 1981619

3.Nucleotide sequence and analysis of the Vibrio alginolyticus sucrose uptake-encoding region. Blatch GL, Scholle RR, Woods DR. Gene 95, 17-23, (1990). View articlePMID: 2174811

GO terms

biological process

  • None

cellular component

  • None

Cross References

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