F
IPR002218

tRNA uridine 5-carboxymethylaminomethyl modification enzyme MnmG-related

InterPro entry
Short nameMnmG-rel
Overlapping
homologous
superfamilies
 
family relationships

Description

MnmG (also known as GidA) is a tRNA modification enzyme found in bacteria and mitochondria. Though its precise molecular function of these proteins is not known, it is involved in the 5-carboxymethylaminomethyl modification of the wobble uridine base in some tRNAs
[1, 2]
. Sequence variations in the human mitochondrial protein may influence the severity of aminoglycoside-induced deafness
[3]
.

This entry includes MnmG and related proteins, such as the methylenetetrahydrofolate--tRNA-(uracil-5-)-methyltransferase enzyme TrmFO.

References

1.Mitochondria-specific RNA-modifying enzymes responsible for the biosynthesis of the wobble base in mitochondrial tRNAs. Implications for the molecular pathogenesis of human mitochondrial diseases. Umeda N, Suzuki T, Yukawa M, Ohya Y, Shindo H, Watanabe K, Suzuki T. J. Biol. Chem. 280, 1613-24, (2005). View articlePMID: 15509579

2.Translational misreading: a tRNA modification counteracts a +2 ribosomal frameshift. Bregeon D, Colot V, Radman M, Taddei F. Genes Dev. 15, 2295-306, (2001). View articlePMID: 11544186

3.Phenotype of non-syndromic deafness associated with the mitochondrial A1555G mutation is modulated by mitochondrial RNA modifying enzymes MTO1 and GTPBP3. Bykhovskaya Y, Mengesha E, Wang D, Yang H, Estivill X, Shohat M, Fischel-Ghodsian N. Mol. Genet. Metab. 83, 199-206, (2004). View articlePMID: 15542390

GO terms

cellular component

  • None

Cross References

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