F
IPR002293

Amino acid/polyamine transporter I

InterPro entry
Short nameAA/rel_permease1
family relationships

Description

Amino acid permeases are integral membrane proteins involved in the transport of amino acids into the cell. A number of such proteins have been found to be evolutionary related
[1, 2, 3]
. These proteins include several yeast specific and general amino acid permeases; Emericella nidulans (Aspergillus nidulans) proline transport protein (gene prnB); Trichoderma harzianum amino acid permease INDA1; Salmonella typhimurium L-asparagine permease (gene ansP); and several Escherichia coli and other bacterial permeases and transport proteins. These proteins seem to contain up to 12 transmembrane segments. This entry consists of members of the amino acid-polyamine-organocation (APC) superfamily
[4]
.

Also included in this entry is the methylthioribose transporter mtrA from Bacillus subtilis, which transports methylthioribose into the cell
[5]
.

References

1.Evolutionary relationship and secondary structure predictions in four transport proteins of Saccharomyces cerevisiae. Weber E, Chevallier MR, Jund R. J. Mol. Evol. 27, 341-50, (1988). View articlePMID: 3146645

2.Nucleotide sequence of the Saccharomyces cerevisiae PUT4 proline-permease-encoding gene: similarities between CAN1, HIP1 and PUT4 permeases. Vandenbol M, Jauniaux JC, Grenson M. Gene 83, 153-9, (1989). View articlePMID: 2687114

3.Mammalian integral membrane receptors are homologous to facilitators and antiporters of yeast, fungi, and eubacteria. Reizer J, Finley K, Kakuda D, MacLeod CL, Reizer A, Saier MH Jr. Protein Sci. 2, 20-30, (1993). View articlePMID: 8382989

4.The amino acid/polyamine/organocation (APC) superfamily of transporters specific for amino acids, polyamines and organocations. Jack DL, Paulsen IT, Saier MH. Microbiology (Reading, Engl.) 146 ( Pt 8), 1797-814, (2000). PMID: 10931886

5.Bacillus subtilis, the model Gram-positive bacterium: 20 years of annotation refinement. Borriss R, Danchin A, Harwood CR, Medigue C, Rocha EPC, Sekowska A, Vallenet D. Microb Biotechnol 11, 3-17, (2018). View articlePMID: 29280348

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