F
IPR002406

Natriuretic peptide, C type

InterPro entry
Short nameC_natriurtcpep
family relationships

Description

Atrial natriuretic peptides (ANPs) are vertebrate hormones that play an important role in the control of cardiovascular homeostatis, and sodium and water balance in general
[1, 2]
. There are different NPs that vary in length but share a common core. All are processed from a single precursor.

A disulphide bond resident in the C-terminal section is required for full activity of atriopeptins. The family of NPs includes structurally-related peptides that elicit similar pharmacological spectra. Amongst these are brain natriuretic peptide (BNP); C-type natriuretic peptide (CNP); ventricular natriuretic peptide (VNP)
[3]
; and Dendroaspis angusticeps (Eastern green mamba) natriuretic peptide (DNP)
[4]
.

C-type natriuretic peptide has vasorelaxant and cGMP-stimulating activities.

References

1.Atrial natriuretic factor and related peptide hormones. Rosenzweig A, Seidman CE. Annu. Rev. Biochem. 60, 229-55, (1991). View articlePMID: 1652921

2.Atrial natriuretic factor. Inagami T. J. Biol. Chem. 264, 3043-6, (1989). View articlePMID: 2536732

3.A novel natriuretic peptide isolated from eel cardiac ventricles. Takei Y, Takahashi A, Watanabe TX, Nakajima K, Sakakibara S. FEBS Lett. 282, 317-20, (1991). View articlePMID: 1828035

4.A new member of the natriuretic peptide family is present in the venom of the green mamba (Dendroaspis angusticeps). Schweitz H, Vigne P, Moinier D, Frelin C, Lazdunski M. J. Biol. Chem. 267, 13928-32, (1992). View articlePMID: 1352773

GO terms

biological process

  • None
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