D
IPR002478

PUA domain

InterPro entry
Short namePUA
Overlapping
homologous
superfamilies
 
domain relationships

Description

The PUA (PseudoUridine synthase and Archaeosine transglycosylase) domain was named after the proteins in which it was first found
[1]
. PUA is a highly conserved RNA-binding motif found in a wide range of archaeal, bacterial and eukaryotic proteins, including enzymes that catalyse tRNA and rRNA post-transcriptional modifications, proteins involved in ribosome biogenesis and translation, as well as in enzymes involved in proline biosynthesis
[3, 4, 6]
. The structures of several PUA-RNA complexes reveal a common RNA recognition surface, but also some versatility in the way in which the motif binds to RNA
[6, 2]
. This domain has an α/β architecture consisting of six β-strands and two short α-helices
[6]
. PUA motifs are involved in dyskeratosis congenita and cancer, pointing to links between RNA metabolism and human diseases
[5]
.

References

1.Novel predicted RNA-binding domains associated with the translation machinery. Aravind L, Koonin EV. J. Mol. Evol. 48, 291-302, (1999). View articlePMID: 10093218

2.The PUA domain - a structural and functional overview. Perez-Arellano I, Gallego J, Cervera J. FEBS J. 274, 4972-84, (2007). View articlePMID: 17803682

3.The structure of the RNA m5C methyltransferase YebU from Escherichia coli reveals a C-terminal RNA-recruiting PUA domain. Hallberg BM, Ericsson UB, Johnson KA, Andersen NM, Douthwaite S, Nordlund P, Beuscher AE 4th, Erlandsen H. J. Mol. Biol. 360, 774-87, (2006). View articlePMID: 16793063

4.The RNA-binding PUA domain of archaeal tRNA-guanine transglycosylase is not required for archaeosine formation. Sabina J, Soll D. J. Biol. Chem. 281, 6993-7001, (2006). View articlePMID: 16407303

5.Crystal structure of an H/ACA box ribonucleoprotein particle. Li L, Ye K. Nature 443, 302-7, (2006). View articlePMID: 16943774

6.Protein universe containing a PUA RNA-binding domain. Cerrudo CS, Ghiringhelli PD, Gomez DE. FEBS J 281, 74-87, (2014). PMID: 24393395

GO terms

biological process

  • None

molecular function

cellular component

  • None

Cross References

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