IPR002586
CobQ/CobB/MinD/ParA nucleotide binding domain
InterPro entry
Short name | CobQ/CobB/MinD/ParA_Nub-bd_dom |
Overlapping homologous superfamilies |
Description
This domain is found in various cobyrinic acid a,c-diamide synthases. These include CbiA (
P29946) and CbiP (
Q05597) from S. typhimurium
[2], and CobQ (
Q52686) from R. capsulatus
[1]. These amidases catalyse amidations to various side chains of hydrogenobyrinic acid or cobyrinic acid a,c-diamide in the biosynthesis of cobalamin (vitamin B12) from uroporphyrinogen III. Vitamin B12 is an important cofactor and an essential nutrient for many plants and animals and is primarily produced by bacteria
[2].
References
1.Identification and sequence analysis of genes involved in late steps in cobalamin (vitamin B12) synthesis in Rhodobacter capsulatus. Pollich M, Klug G. J. Bacteriol. 177, 4481-7, (1995). View articlePMID: 7635831
2.Characterization of the cobalamin (vitamin B12) biosynthetic genes of Salmonella typhimurium. Roth JR, Lawrence JG, Rubenfield M, Kieffer-Higgins S, Church GM. J. Bacteriol. 175, 3303-16, (1993). View articlePMID: 8501034
Further reading
3. A family of ATPases involved in active partitioning of diverse bacterial plasmids. Motallebi-Veshareh M, Rouch DA, Thomas CM. Mol. Microbiol. 4, 1455-63, (1990). View articlePMID: 2149583
Cross References
Contributing Member Database Entry
- Pfam:PF01656
Representative structure
3kjh: Zn-bound state of CooC1