IPR002654
Glycosyl transferase, family 25
InterPro entry
Short name | Glyco_trans_25 |
Description
The biosynthesis of disaccharides, oligosaccharides and polysaccharides involves the action of hundreds of different glycosyltransferases. These enzymes catalyse the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. A classification of glycosyltransferases using nucleotide diphospho-sugar, nucleotide monophospho-sugar and sugar phosphates (
2.4.1.-) and related proteins into distinct sequence based families has been described
[2]. This classification is available on the CAZy (CArbohydrate-Active EnZymes) web site. The same three-dimensional fold is expected to occur within each of the families. Because 3-D structures are better conserved than sequences, several of the families defined on the basis of sequence similarities may have similar 3-D structures and therefore form 'clans'.
References
1.Molecular analysis of a locus for the biosynthesis and phase-variable expression of the lacto-N-neotetraose terminal lipopolysaccharide structure in Neisseria meningitidis. Jennings MP, Hood DW, Peak IR, Virji M, Moxon ER. Mol. Microbiol. 18, 729-40, (1995). View articlePMID: 8817494
2.A classification of nucleotide-diphospho-sugar glycosyltransferases based on amino acid sequence similarities. Campbell JA, Davies GJ, Bulone V, Henrissat B. Biochem. J. 326 ( Pt 3), 929-39, (1997). View articlePMID: 9334165