F
IPR002654

Glycosyl transferase, family 25

InterPro entry
Short nameGlyco_trans_25

Description

The biosynthesis of disaccharides, oligosaccharides and polysaccharides involves the action of hundreds of different glycosyltransferases. These enzymes catalyse the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. A classification of glycosyltransferases using nucleotide diphospho-sugar, nucleotide monophospho-sugar and sugar phosphates (
2.4.1.-
) and related proteins into distinct sequence based families has been described
[2]
. This classification is available on the CAZy (CArbohydrate-Active EnZymes) web site. The same three-dimensional fold is expected to occur within each of the families. Because 3-D structures are better conserved than sequences, several of the families defined on the basis of sequence similarities may have similar 3-D structures and therefore form 'clans'.

Glycosyltransferase family 25 (
GT25
) comprises enzymes with only one known activity: as a lipopolysaccharide biosynthesis protein. These enzymes catalyse the transfer of various sugars onto the growing lipopolysaccharide chain during its biosynthesis
[1]
.

References

1.Molecular analysis of a locus for the biosynthesis and phase-variable expression of the lacto-N-neotetraose terminal lipopolysaccharide structure in Neisseria meningitidis. Jennings MP, Hood DW, Peak IR, Virji M, Moxon ER. Mol. Microbiol. 18, 729-40, (1995). View articlePMID: 8817494

2.A classification of nucleotide-diphospho-sugar glycosyltransferases based on amino acid sequence similarities. Campbell JA, Davies GJ, Bulone V, Henrissat B. Biochem. J. 326 ( Pt 3), 929-39, (1997). View articlePMID: 9334165

Cross References

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