F
IPR002695

Bifunctional purine biosynthesis protein PurH-like

InterPro entry
Short namePurH-like
Overlapping
homologous
superfamilies
 

Description

This is a family of bifunctional enzymes catalysing the last two steps inde novopurine biosynthesis. The bifunctional enzyme is found in both prokaryotes and eukaryotes. The second last step is catalysed by 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase
2.1.2.3
(AICARFT), this enzyme catalyses the formylation of AICAR with 10-formyl-tetrahydrofolate to yield FAICAR and tetrahydrofolate
[1]
. The last step is catalysed by IMP (Inosine monophosphate) cyclohydrolase
3.5.4.10
(IMPCHase), cyclizing FAICAR (5-formylaminoimidazole-4-carboxamide ribonucleotide) to IMP
[1]
.

References

1.Molecular cloning and expression of a rat cDNA encoding 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase. Akira T, Komatsu M, Nango R, Tomooka A, Konaka K, Yamauchi M, Kitamura Y, Nomura S, Tsukamoto I. Gene 197, 289-93, (1997). View articlePMID: 9332377

GO terms

Cross References

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