D
IPR003112

Olfactomedin-like domain

InterPro entry
Short nameOlfac-like_dom

Description

The olfactomedin-like or OLF domain is a module of ~260 residues present in metazoan secreted glycoproteins with a characteristic tissue-specific expression. The domain is named after bullfrog olfactomedin, an extracellular matrix protein of olfactory neuroepithelium, whereof it forms the C-terminal part. Other proteins of the olfactomedin family contain the OLF domain in the C-terminal part, while the N terminus is more variable. Proteins of the latrophilin subfamily have an OLF domain in the N-terminal extracellular part, C-terminal to a SUEL-type lectin domain, and their C-terminal part contains domains of the G-protein coupled receptors family 2. Some OLF domain proteins are involved in the formation of the extracellular matrix, e.g. bullfrog olfactomedin, sea urchin amassin and C. elegans unc-122. In addition, OLF domain proteins can function in developmental processes, e.g. noelin and tiarin
[1, 4, 2, 3]
.

Secondary structure predictions show that the OLF domain contains several β-strands
[4, 2, 3]
. A disulfide bond between two conserved cysteines within the OLF domain of human myocilin is implicated in mutations associated with severe forms of primary open angle glaucoma
[2]
.

References

1.Optimedin: a novel olfactomedin-related protein that interacts with myocilin. Torrado M, Trivedi R, Zinovieva R, Karavanova I, Tomarev SI. Hum. Mol. Genet. 11, 1291-301, (2002). View articlePMID: 12019210

2.Expression and characterization of the olfactomedin domain of human myocilin. Nagy I, Trexler M, Patthy L. Biochem. Biophys. Res. Commun. 302, 554-61, (2003). View articlePMID: 12615070

3.hOLF44, a secreted glycoprotein with distinct expression pattern, belongs to an uncharacterized olfactomedin-like subfamily newly identified by phylogenetic analysis. Zeng LC, Liu F, Zhang X, Zhu ZD, Wang ZQ, Han ZG, Ma WJ. FEBS Lett. 571, 74-80, (2004). View articlePMID: 15280020

4.Identification and characterization of a novel member of olfactomedin-related protein family, hGC-1, expressed during myeloid lineage development. Zhang J, Liu WL, Tang DC, Chen L, Wang M, Pack SD, Zhuang Z, Rodgers GP. Gene 283, 83-93, (2002). View articlePMID: 11867215

Cross References

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