F
IPR003389

Adenovirus packaging protein 1

InterPro entry
Short nameAdeno_IVa2

Description

Packaging protein 1 (also known as IVa2) is a component of the packaging machinery which encapsidates the viral DNA into preformed capsids and transcriptional activator of the viral major late promoter (MLP)
[3]
. It binds, along with packaging proteins 2 and 3, to the specific packaging sequence on the left end of viral genomic DNA and displays ATPase activity thereby providing the power stroke of the packaging machinery
[1, 2]
.

References

1.Presence of the adenovirus IVa2 protein at a single vertex of the mature virion. Christensen JB, Byrd SA, Walker AK, Strahler JR, Andrews PC, Imperiale MJ. J. Virol. 82, 9086-93, (2008). View articlePMID: 18614642

2.Components of Adenovirus Genome Packaging. Ahi YS, Mittal SK. Front Microbiol 7, 1503, (2016). PMID: 27721809

3.Properties of the adenovirus IVa2 gene product, an effector of late-phase-dependent activation of the major late promoter. Lutz P, Kedinger C. J. Virol. 70, 1396-405, (1996). PMID: 8627656

GO terms

molecular function

  • None

cellular component

  • None
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