IPR003395
RecF/RecN/SMC, N-terminal
InterPro entry
Short name | RecF/RecN/SMC_N |
Overlapping homologous superfamilies |
Description
This domain is found at the N terminus of structural maintenance of chromosomes (SMC) proteins, which function together with other proteins in a range of chromosomal transactions, including chromosome condensation, sister-chromatid cohesion, recombination, DNA repair and epigenetic silencing of gene expression
[1]. The eukaryotic SMC proteins form two kind of heterodimers: the SMC1/SMC3 and the SMC2/SMC4 types. These heterodimers constitute an essential part of higher order complexes, which are involved in chromatin and DNA dynamics
[2]. This domain is also found in RecF and RecN proteins, which are involved in DNA metabolism and recombination.
This domain is also found in urease accessory protein 2 (URE2) which is a central component of cohesin, a complex required for chromosome cohesion during the cell cycle, and Is unrelated to urease function in C.neoformans
[3].
References
1.Molecular architecture of SMC proteins and the yeast cohesin complex. Haering CH, Lowe J, Hochwagen A, Nasmyth K. Mol. Cell 9, 773-88, (2002). View articlePMID: 11983169
2.Structural maintenance of chromosomes (SMC) proteins: conserved molecular properties for multiple biological functions. Strunnikov AV, Jessberger R. Eur. J. Biochem. 263, 6-13, (1999). View articlePMID: 10429180
3.Factors required for activation of urease as a virulence determinant in Cryptococcus neoformans. Singh A, Panting RJ, Varma A, Saijo T, Waldron KJ, Jong A, Ngamskulrungroj P, Chang YC, Rutherford JC, Kwon-Chung KJ. mBio 4, e00220-13, (2013). View articlePMID: 23653445
Contributing Member Database Entry
- Pfam:PF02463
Representative structure
6qj0: Crystal structure of the C. thermophilum condensin Smc2 ATPase head (crystal form II)