D
IPR003395

RecF/RecN/SMC, N-terminal

InterPro entry
Short nameRecF/RecN/SMC_N
Overlapping
homologous
superfamilies
 

Description

This domain is found at the N terminus of structural maintenance of chromosomes (SMC) proteins, which function together with other proteins in a range of chromosomal transactions, including chromosome condensation, sister-chromatid cohesion, recombination, DNA repair and epigenetic silencing of gene expression
[1]
. The eukaryotic SMC proteins form two kind of heterodimers: the SMC1/SMC3 and the SMC2/SMC4 types. These heterodimers constitute an essential part of higher order complexes, which are involved in chromatin and DNA dynamics
[2]
. This domain is also found in RecF and RecN proteins, which are involved in DNA metabolism and recombination.

This domain is also found in urease accessory protein 2 (URE2) which is a central component of cohesin, a complex required for chromosome cohesion during the cell cycle, and Is unrelated to urease function in C.neoformans
[3]
.

References

1.Molecular architecture of SMC proteins and the yeast cohesin complex. Haering CH, Lowe J, Hochwagen A, Nasmyth K. Mol. Cell 9, 773-88, (2002). View articlePMID: 11983169

2.Structural maintenance of chromosomes (SMC) proteins: conserved molecular properties for multiple biological functions. Strunnikov AV, Jessberger R. Eur. J. Biochem. 263, 6-13, (1999). View articlePMID: 10429180

3.Factors required for activation of urease as a virulence determinant in Cryptococcus neoformans. Singh A, Panting RJ, Varma A, Saijo T, Waldron KJ, Jong A, Ngamskulrungroj P, Chang YC, Rutherford JC, Kwon-Chung KJ. mBio 4, e00220-13, (2013). View articlePMID: 23653445

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