F
IPR003539

Cytolethal distending toxin B

InterPro entry
Short nameCD_toxinB
Overlapping
homologous
superfamilies
 

Description

Cytolethal distending toxin (CDT) is a secreted protein toxin produced by a number of Gram-negative disease-causing bacteria. CDT causes cell cycle arrest and eventual cell death in eukaryotic cells, as a result of chromosomal DNA damage caused by the catalytic, DNase I-like, CdtB subunit. Bacterial CDTs are generally comprised of three subunits, CdtA, -B and -C
[2]
. CdtB is translocated into the host cell, where it acts as a genotoxin
[4, 3]
. CdtA and CdtC are needed for cell surface binding and cellular entry, and it is likely that they remain associated with the membrane, when CdtB is internalized. CdtB enters the target nucleus via nuclear translocation signal domain(s)
[1]
.

References

1.An N-terminal segment of the active component of the bacterial genotoxin cytolethal distending toxin B (CDTB) directs CDTB into the nucleus. Nishikubo S, Ohara M, Ueno Y, Ikura M, Kurihara H, Komatsuzawa H, Oswald E, Sugai M. J. Biol. Chem. 278, 50671-81, (2003). View articlePMID: 12947116

2.Cytolethal distending toxin (CDT): a bacterial weapon to control host cell proliferation? De Rycke J, Oswald E. FEMS Microbiol. Lett. 203, 141-8, (2001). View articlePMID: 11583839

3.Cytolethal distending toxin: creating a gap in the cell cycle. Heywood W, Henderson B, Nair SP. J. Med. Microbiol. 54, 207-16, (2005). View articlePMID: 15713603

4.Assembly and function of a bacterial genotoxin. Nesic D, Hsu Y, Stebbins CE. Nature 429, 429-33, (2004). View articlePMID: 15164065

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