F
IPR003710

Ketopantoate reductase ApbA/PanE

InterPro entry
Short nameApbA

Description

ApbA, the ketopantoate reductase enzyme
1.1.1.169
of Salmonella typhimurium is required for the synthesis of thiamine via the alternative pyrimidine biosynthetic pathway
[1]
. Precursors to the pyrimidine moiety of thiamine are synthesized de novo by the purine biosynthetic pathway or the alternative pyrimidine biosynthetic (APB) pathway. The ApbA protein catalyzes the NADPH-specific reduction of ketopantoic acid to pantoic acid. This activity had previously been associated with the pantothenate biosynthetic gene panE
[2]
. ApbA and PanE are allelic
[2]
.

This entry also include budding yeast Pan5, which is a 2-dehydropantoate 2-reductase involved in the (R)-pantothenate biosynthesis
[3]
.

References

1.ApbA, the ketopantoate reductase enzyme of Salmonella typhimurium is required for the synthesis of thiamine via the alternative pyrimidine biosynthetic pathway. Frodyma ME, Downs D. J. Biol. Chem. 273, 5572-6, (1998). View articlePMID: 9488683

2.The panE gene, encoding ketopantoate reductase, maps at 10 minutes and is allelic to apbA in Salmonella typhimurium. Frodyma ME, Downs D. J. Bacteriol. 180, 4757-9, (1998). View articlePMID: 9721324

3.Saccharomyces cerevisiae is capable of de Novo pantothenic acid biosynthesis involving a novel pathway of beta-alanine production from spermine. White WH, Gunyuzlu PL, Toyn JH. J. Biol. Chem. 276, 10794-800, (2001). View articlePMID: 11154694

GO terms

Cross References

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