D
IPR003877

SPRY domain

InterPro entry
Short nameSPRY_dom
Overlapping
homologous
superfamilies
 
domain relationships

Description

The SPRY domain is named from SPla and the RYanodine Receptor and it is found in many eukaryotic proteins with a wide range of functions. It is a protein interaction module involved in many important signalling pathways like RNA processing, regulation of histone H3 methylation, innate immunity or embryonic development
[3, 2, 4]
. It can be divided into 11 subfamilies based on amino acid sequence similarity or the presence of additional protein domains. The greater SPRY family is divided into the SPRY/B30.2 (which contains a PRY extension at the N-terminal) and SPRY-only sub-families which are preceded by a subdomain that is structurally similar to the PRY region
[2]
. SPRY/B30.2 structures revealed a bent β-sandwich fold comprised of two β-sheets. The PRY domain consists of three β-strands tightly packed against ten other β-strands which form the SPRY component of the B30.2 domain. The β-strands are linked by loops and form two anti-parallel β-sheets
[2]
. Distant homologues are domains in butyrophilin/marenostrin/pyrin
[1]
.

References

1.SPRY domains in ryanodine receptors (Ca(2+)-release channels). Ponting C, Schultz J, Bork P. Trends Biochem. Sci. 22, 193-4, (1997). View articlePMID: 9204703

2.Structure and function of the SPRY/B30.2 domain proteins involved in innate immunity. D'Cruz AA, Babon JJ, Norton RS, Nicola NA, Nicholson SE. Protein Sci. 22, 1-10, (2013). View articlePMID: 23139046

3.Structural basis for protein recognition by B30.2/SPRY domains. Woo JS, Suh HY, Park SY, Oh BH. Mol. Cell 24, 967-76, (2006). View articlePMID: 17189197

4.SPRYSEC Effectors: A Versatile Protein-Binding Platform to Disrupt Plant Innate Immunity. Diaz-Granados A, Petrescu AJ, Goverse A, Smant G. Front Plant Sci 7, 1575, (2016). PMID: 27812363

GO terms

biological process

  • None

cellular component

  • None

Cross References

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