IPR003894
TAFH/NHR1
InterPro entry
Short name | TAFH_NHR1 |
Overlapping homologous superfamilies |
Description
The TAF homology (TAFH) or Nervy homology region 1 (NHR1) domain is a domain of 95-100 amino acids present in eukaryotic proteins of the MTG/ETO family and whereof the core ~75-80 residues occur in TAF proteins. The transcription initiation TFIID complex is composed of TATA binding protein (TBP) and a number of TBP-associated factors (TAFs). The TAFH/NHR1 domain is named after fruit fly TATA-box-associated factor 110 (TAF110), human TAF105 and TAF130, and the fruit fly protein Nervy, which is a homologue of human MTG8/ETO
[1, 2]. The human eight twenty-one (ETO, MTG8 or CBFA2T1) and related myeloid transforming gene products MTGR1 and MTG16 as well as the Nervy protein contain the NHR1-4 domains. The NHR1/TAFH domain occurs in the N-terminal part of these proteins, while a MYND-type zinc finger forms the NHR4 domain
[3]. The TAFH/NHR1 domain can be involved in protein-protein interactions, e.g in MTG8/ETO with HSP90 and Gfi-1
[4].
References
1.The AML1-MTG8 leukemic fusion protein forms a complex with a novel member of the MTG8(ETO/CDR) family, MTGR1. Kitabayashi I, Ida K, Morohoshi F, Yokoyama A, Mitsuhashi N, Shimizu K, Nomura N, Hayashi Y, Ohki M. Mol. Cell. Biol. 18, 846-58, (1998). View articlePMID: 9447981
2.CBFA2T1, a gene rearranged in human leukemia, is a member of a multigene family. Calabi F, Cilli V. Genomics 52, 332-41, (1998). View articlePMID: 9790752
3.The ETO (MTG8) gene family. Davis JN, McGhee L, Meyers S. Gene 303, 1-10, (2003). View articlePMID: 12559562
GO terms
biological process
molecular function
- None
cellular component
- None
Cross References
PROSITE Doc
Representative structure
2p6v: Structure of TAFH domain of the human TAF4 subunit of TFIID