D
IPR003894

TAFH/NHR1

InterPro entry
Short nameTAFH_NHR1
Overlapping
homologous
superfamilies
 

Description

The TAF homology (TAFH) or Nervy homology region 1 (NHR1) domain is a domain of 95-100 amino acids present in eukaryotic proteins of the MTG/ETO family and whereof the core ~75-80 residues occur in TAF proteins. The transcription initiation TFIID complex is composed of TATA binding protein (TBP) and a number of TBP-associated factors (TAFs). The TAFH/NHR1 domain is named after fruit fly TATA-box-associated factor 110 (TAF110), human TAF105 and TAF130, and the fruit fly protein Nervy, which is a homologue of human MTG8/ETO
[1, 2]
. The human eight twenty-one (ETO, MTG8 or CBFA2T1) and related myeloid transforming gene products MTGR1 and MTG16 as well as the Nervy protein contain the NHR1-4 domains. The NHR1/TAFH domain occurs in the N-terminal part of these proteins, while a MYND-type zinc finger forms the NHR4 domain
[3]
. The TAFH/NHR1 domain can be involved in protein-protein interactions, e.g in MTG8/ETO with HSP90 and Gfi-1
[4]
.

References

1.The AML1-MTG8 leukemic fusion protein forms a complex with a novel member of the MTG8(ETO/CDR) family, MTGR1. Kitabayashi I, Ida K, Morohoshi F, Yokoyama A, Mitsuhashi N, Shimizu K, Nomura N, Hayashi Y, Ohki M. Mol. Cell. Biol. 18, 846-58, (1998). View articlePMID: 9447981

2.CBFA2T1, a gene rearranged in human leukemia, is a member of a multigene family. Calabi F, Cilli V. Genomics 52, 332-41, (1998). View articlePMID: 9790752

3.The ETO (MTG8) gene family. Davis JN, McGhee L, Meyers S. Gene 303, 1-10, (2003). View articlePMID: 12559562

4.Association of MTG8 (ETO/CDR), a leukemia-related protein, with serine/threonine protein kinases and heat shock protein HSP90 in human hematopoietic cell lines. Komori A, Sueoka E, Fujiki H, Ishii M, Kozu T. Jpn. J. Cancer Res. 90, 60-8, (1999). PMID: 10076566

GO terms

molecular function

  • None

cellular component

  • None

Cross References

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