D
IPR004170

WWE domain

InterPro entry
Short nameWWE_dom
Overlapping
homologous
superfamilies
 
domain relationships

Description

The WWE domain is named after three of its conserved residues and is predicted to mediate specific protein-protein interactions in ubiquitin and ADP ribose conjugation systems. This domain is found as a tandem repeat at the N-terminal of Deltex, a cytosolic effector of Notch signalling thought to bind the N-terminal of the Notch receptor
[1]
. It is also found as an interaction module in protein ubiquination and ADP ribosylation proteins
[2]
.

References

1.Structure and Notch receptor binding of the tandem WWE domain of Deltex. Zweifel ME, Leahy DJ, Barrick D. Structure 13, 1599-611, (2005). View articlePMID: 16271883

2.The WWE domain: a common interaction module in protein ubiquitination and ADP ribosylation. Aravind L. Trends Biochem. Sci. 26, 273-5, (2001). View articlePMID: 11343911

Cross References

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