F
IPR004402

Purine nucleoside phosphorylase DeoD-type

InterPro entry
Short nameDeoD-type
Overlapping
homologous
superfamilies
 

Description

Purine nucleoside phosphorylase
2.4.2.1
, also called inosine phosphorylase (pnp), catalyses the cleavage of the glycosidic bond of ribo- and deoxyribonucleosides in the presence of orthophospate
[1]
. It is specific for guanosine, inosine and adenosine and cleavage results in formation of their respective bases and ribose phosphate molecules. Together with adenosine deanimase,
IPR006330
, purine nucleoside phophorylase is responsible for purine catabolism as part of the salvage pathway of nucleotides and nucleosides.

References

1.Purine nucleoside phosphorylases: properties, functions, and clinical aspects. Bzowska A, Kulikowska E, Shugar D. Pharmacol. Ther. 88, 349-425, (2000). View articlePMID: 11337031

GO terms

Cross References

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